The Neurobiology of Addiction

Hardcover | March 17, 2010

EditorTrevor Robbins, Barry Everitt, David Nutt

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In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, andamphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlyingaddiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural addictions suchas gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychologicaltheories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology.The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.

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From the Publisher

In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, andamphetamine, as well as legal drugs such as ...

Professor Robbins is Professor of Cognitive Neuroscience and Head of the Department of Experimental Psychology at the University of Cambridge. He is also Director of the Cambridge MRC-Wellcome Trust Behavioural and Clinical Neuroscience Institute (BCNI), the main objective of which is to inter-relate basic and clinical research in psy...

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Format:HardcoverDimensions:308 pages, 9.69 × 6.73 × 0.03 inPublished:March 17, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199562156

ISBN - 13:9780199562152

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Table of Contents

T. W. Robbins, B. J. Everitt and D. J. Nutt: Introduction. The neurobiology of drug addiction: new vistasG. F. Koob and M. Le Moal: Neurobiological mechanisms for opponent motivational processes in addictionB. J. Everitt, D. Belin, D. Economidou, Y. Pelloux, J. W. Dalley and T. W. Robbins: Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addictionT. E. Robinson and K. C. Berridge: The incentive sensitization theory of addiction: some current issuesJ. Stewart: Psychological and neural mechanisms of relapseA. Markou: Neurobiology of nicotine dependenceD. N. Stephens and T. Duka: Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortexM. N. Potenza: The neurobiology of pathological gambling and drug addiction: an overview and new findingsN. D. Volkow, G.-J. Wang, J. S. Fowler and F. Telang: Overlapping neuronal circuits in addiction and obesity: evidence of systems pathologyJ. C. Crabbe: Neurogenetic studies of alcohol addictionC. C. Y. Wong and G. Schumann: Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disordersM. A. Nader, P. W. Czoty, R. W. Gould and N. V. Riddick: Positron emission tomography imaging studies of dopamine receptors in primate models of addictionH. S. Crombag, J. M. Bossert, E. Koya and Y. Shaham: Context-induced relapse to drug seeking: a reviewE. J. Nestler: Transcriptional mechanisms of addiction: role of changes in FosBT. J. R. Beveridge, K. E. Gill, C. A. Hanlon and L. J. Porrino: Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeysH. Garavan, J. N. Kaufman and R. Hester: Acute effects of cocaine on the neurobiology of cognitive controlC. P. O'Brien: Evidence-based treatments of addiction

Editorial Reviews

Review from other book by this author ''...the editors of the present volume...assembled a stellar cast and prepared an effective, concise volume.'' --Steven P. Wise, Trends in Cognitive Sciences, Vol. 3, No. 7