The Neurobiology of Pain: (Molecular and Cellular Neurobiology)

Hardcover | September 22, 2005

EditorStephen Hunt, Martin Koltzenburg

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The last decade has seen major advances in the neurobiology of pain, primarily resulting from a deeper understanding of the way in which pain signals are coded and processed in the nervous system. This volume in the Molecular and Cellular Neurobiology series is the first book for many yearsto present an integrated overview of the current state of research into the neurobiology of chronic and acute pain. While recent molecular aspects of nociception are covered in some detail, the book also emphasises the importance of viewing the pain experience as the co-ordinated response of many different areas of the nervous system. The molecular advances are set in the context of the neurobiological system ofpain processing. The appropriate behavioural response to injury can therefore be thought of as the result of the integration of information processed within areas of the brain concerned with cognition, affect, sensory discrimination and movement. Chapters cover recent advances in nociceptor transduction mechanisms, nociceptor plasticity and the biochemical anatomy of pain pathways. Other contributions are concerned with the development of pain systems and with the central processing of nociceptive information studied with brain imagingtechniques. Several chapters additionally cover the mechanisms of clinically important pain states such as neuropathic pain, cancer related pain and migraine. This volume presents a state-of-the-art account of the neurobiological basis of pain, edited and written by the leading scientists in this field.

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The last decade has seen major advances in the neurobiology of pain, primarily resulting from a deeper understanding of the way in which pain signals are coded and processed in the nervous system. This volume in the Molecular and Cellular Neurobiology series is the first book for many yearsto present an integrated overview of the cur...

Stephen Hunt is at Department of Anatomy and Developmental Biology, University College London, UK. Martin Koltzenburg is at Institute of Child Health, Institute of Neurology, University College London, UK.

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Format:HardcoverDimensions:416 pages, 9.45 × 6.61 × 1.1 inPublished:September 22, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198515618

ISBN - 13:9780198515616

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Table of Contents

1. Michael J Caterina, Michael Gold and Richard A Meyer: Molecular biology of nociceptors2. Stephen B McMahon and John V Priestley: Nociceptor plasticity3. Andrew Todd and Alfredo Ribeiro da Silva: Molecular architecture of the dorsal horn4. Michael Salter and Clifford J Woolf: Cellular and molecular mechanisms of central sensitization5. Martin Koltzenburg: Mechanisms of peripheral neuropathic pain6. Anthony Dickenson and Rie Suzuki: Targets in pain and analgesia7. Stephen P Hunt and Herve Bester: The ascending pain pathways8. Tony L Yaksh and Patrick W Mantyh: Spinal delivery of drugs in pain control9. Maria Fitzgerald and Amy MacDermott: The development of pain systems10. Jennifer M A Laird and Hans-Georg Schaible: Visceral and deep somatic pain11. Thelma Lovick and Richard Bandler: The organization of the midbrain periaqueductal grey matter and the integration of pain behaviours12. G F Gebhart and H Proudfit: Descending control of pain processing13. Herta Flor and Catherine Bushnell: Central imaging of pain14. Peter Goadsby and Michel Ferrari: Headache15. P.W. Mantyh and T.L. Yaksh: An integrative approach to the control of cancer pain