The Neuroendocrine Immune Network In Ageing by R.h. StraubThe Neuroendocrine Immune Network In Ageing by R.h. Straub

The Neuroendocrine Immune Network In Ageing

byR.h. StraubEditorEugenio Mocchegiani

Hardcover | October 1, 2004

Pricing and Purchase Info

$329.72 online 
$432.50 list price save 23%
Earn 1649 plum® points

In stock online

Ships free on orders over $25

Not available in stores


The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.
Dr. Eugenio Mocchegiani has 40 years expertise as researcher at INRCA, The Italian National Institute of Health and Science on Aging. For the past 10 years, he has been the Head of the Centre of Nutrition and Aging at INRCA. His field of research concerns the role of endocrine and nutritional factors in immunosenescence, tumurs, infect...
Title:The Neuroendocrine Immune Network In AgeingFormat:HardcoverDimensions:456 pages, 11.25 × 8.7 × 0.98 inPublished:October 1, 2004Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0444516174

ISBN - 13:9780444516176

Look for similar items by category:


Table of Contents

I. Introduction.
Evolutionary aspects for the neuroendocrine immune network and ageing (R.H. Straub).

II. Ageing of the immune system.
Immunosenescence (R. Solana, G. Pawelec). Zinc-binding proteins (metallothionein and ± -2 macroglobulin) as potential biological markers of immunosenescence (E. Mocchegianiet al.). Neutrophil ageing and immunosenescence (S.K. Butcheret al.). Apoptosis and ageing (A. Larbiet al.). MHC-unrestricted cytotoxicity in ageing (M. Provinciali, A. Donnini, R.E. Francesca). Major histocompatibility complex polymorphisms and ageing (G. Candoreet al.).

III. Ageing of the endocrine system.
Neuroplascticity in the human hypothalamus during ageing (M.A. Hofman, D.F. Swaab). The role of growth hormone signalling in the control of ageing (A. Bartkeet al.). Ageing and the adrenal cortex (V. Lamounier-Zepter, S.R. Bornstein). Hormonal changes in ageing men (E. Plas, S. Madersbacher, P. Berger). Ageing and the endocrine circadian system (Y. Touitou, E. Haus). Melatonin rhythms, melatonin supplementation and sleep in old age (R.F. Riemersmaet al.).

IV. Ageing of the nervous system.
Age-related changes of the human autonomic nervous system (M. Agelink, R. Malessa, D. Ziegler). Age-related alterations in autonomic nervous innervation (D.L. Bellinger, K.S. Madden, D. Lorton). Ageing and the neuroendocrine system of the gut (M. El-Salhy). Modulating effects of nutrition on brain ageing (C. Bertoni-Freddariet al.). Ageing-related role of nitric oxide in the brain (S. Mariottoet al.).

V. Links between one global system and another global system during the ageing process.
Introduction (R.H. Straub). Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: Role of zinc (E. Mocchegianiet al.). Adverse lucocorticoid actions and their relevance to brain ageing (K. Dinkel, R.M. Sapolsky). Neuroendocrine immune aspects of osteoporosis during the ageing process (M. Peterlik).

VI. The ageing process and chronic inflammatory diseases.
Neuroendocrine immune mechanisms of accelerated ageing in patients with chronic inflammatory diseases (R.H. Straub, J. Schölmerich, M. Cutolo). Thyroid autoimmunity and ageing (S. Mariotti, G. Pinna, A. Pinchera). The clinical importance of proinflammatory cytokines in elderly populations (H. Bruunsgaard, K. Krabbe).

VII. Conclusions.
Possible new anti-ageing strategies related to neuroendocrine immune interactions (E. Mocchegiani, R.H. Straub). Concluding remarks and future directions (I. Berczi, A. Szentivanyi).

Editorial Reviews

" a welcome addition to biogerontological literature..."

"...good overview of the aging of the immune, neural and endocrine systems."
- Meharvan Singh, PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, U.S.A. (2005)