The Neuromodulators

Hardcover | July 18, 2005

byRonald J. BradleyEditorR. Adron Harris, Peter Jenner

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Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

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Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormo...

John Smythies is a neuropsychiatrist and neuroscientist and has made significant contributions to both these disciplines. Together with Humphrey Osmond he developed the first biochemical theory of schizophrenia-the transmethylation hypothesis. This has recently come back into focus following the finding that DNA methylation is abnormal...

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Format:HardcoverDimensions:296 pages, 9 × 6 × 0.98 inPublished:July 18, 2005Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123668654

ISBN - 13:9780123668653

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Table of Contents

Section I. The Cholinergic System
Part I Introduction
Part II - The Muscarinic System
Part III - The Nicotinic System
Section II. The Dopamine System
Section III. The Norepinephrine System
Section IV. The Adrenaline System
Section V. The Serotonin System
Section VI. Conclusion