The Neuropathology of Schizophrenia: Progress and Interpretation

Hardcover | August 1, 2000

EditorPaul J. Harrison, Gareth W. Roberts

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The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview ofthis rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central tounderstanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these findings, such as the neurodevelopmental hypothesis. Finally, there are chapters considering the conceptual and methodological problems affecting the subject. This is a timely andunique book on this classic and controversial issue, with contributions from many of the leading international experts in the field.

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The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview ofthis rapidly moving field. It starts by des...

Paul Harrison is at University of Oxford. Gareth Roberts is at SmithKline Beecham Pharmaceuticals.

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Format:HardcoverPublished:August 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0192629077

ISBN - 13:9780192629074

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Table of Contents

Introduction1. Structural imaging findings and macroscopic pathology2. Hippocampal pathology3. Cortical pathology: a new generation of quantitative microscopic findings4. Synaptic pathology5. Gliosis and its implications for the disease process6. Cerebral asymmetry7. Functional imaging and neural circuitry in schizophrenia8. Neuropathology and the neurodevelopmental model9. Cortical development and schizophrenia10. The organization of cortical circuitry11. Perspectives from other diseases and lesions12. Animal models of schizophrenia13. A sceptical view of the neuropathology of schizophrenia14. Methodological issues15. Neuropathological consequences of schizophrenia treatments

Editorial Reviews

"Overall, the book presents a comprehensive review of data from many sources."..."This is a book that schizophrenia researchers should have on their bookshelves.British Journal of Psychiatry