The OMICs: Applications in Neuroscience

Paperback | January 14, 2014

EditorGiovanni Coppola

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The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as "OMICs") in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientistscurious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The readeris given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.

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The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as "OMICs") in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientistscurious about the most recent advances in t...

Giovanni Coppola, MD, is Director at the Center for Informatics and Personalized Genomics Semel Institute for Neuroscience and Human Behavior in the Departments of Psychiatry and Neurology at the David Geffen School of Medicine, University of California, Los Angeles.

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Format:PaperbackDimensions:384 pages, 10 × 7 × 0.68 inPublished:January 14, 2014Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199855455

ISBN - 13:9780199855452

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Table of Contents

Section 1. DNA1. Medical DNA Sequencing in Neuroscience2. Epigenomics: an Overview3. The Role Of Epigenomics In Genetically Identical IndividualsSection 2. RNA4. Decoding alternative mRNAs in the OMIC-age5. Transcriptomics: from Differential Expression to Coexpression6. High-Throughput-RNA Interference As A Tool For Discovery in Neuroscience7. The Genetics Of Gene Expression: Multiple Layers and Multiple PlayersSection 3. PROTEIN8. Proteomics9. Focused plasma proteomics for the study of brain aging and neurodegenerationSection 4. CELLS AND CONNECTIONS10. Cellomics: Characterization of Neuronal Subtypes by High-Throughput Transgenic Mouse Models11. Neuroscience and Metabolomics12. Brain Connectomics in Man and Mouse13. Optogenetics14. Characterising the Gut Microbiome: Role in Brain-Gut FunctionSection 5. THERAPEUTICS15. OMICS in Drug Discovery: From Small Molecule Leads to Clinical Candidates16. PharmacogenomicsSection 6. OMICsOME: integration of OMICs data17. Multidimensional Databases Of Animal Models18. Network Biology and Molecular Medicine in the Post Genomic Era: The Systems Pathobiology of Network Medicine