The Oncogene and Tumour Suppressor Gene Factsbook

Other | July 1, 1997

byHesketh, Robin, Robin Hesketh

not yet rated|write a review
The Second Edition ofThe Oncogene and Tumour Suppressor Gene FactsBookhas been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes includingJUN, MYC, andRAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy.

  • Includes much new data on this fast-moving field, including newly discovered oncogenes
  • Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes
  • Contains more than 2000 terms for reference and further research
  • Revised to included signaling pathways, apoptosis, and metastasis

Pricing and Purchase Info

$87.89 online
$114.11 list price (save 22%)
In stock online
Ships free on orders over $25

From the Publisher

The Second Edition ofThe Oncogene and Tumour Suppressor Gene FactsBookhas been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes includingJUN, MYC, andRAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential mat...

Format:OtherDimensions:608 pages, 1 × 1 × 1 inPublished:July 1, 1997Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080538002

ISBN - 13:9780080538006

Customer Reviews of The Oncogene and Tumour Suppressor Gene Factsbook

Reviews

Extra Content

Table of Contents

The Introductory Chapters:
Introduction: Identification of Oncogenes.
Oncogene Activation in Humans.
Proliferation Control Pathways: Oncoprotein Function.
Growth Factor-Related Proteins.
SRC. RASandRAF.
Nuclear Oncoproteins.
ETS. FOSandJUN. MYB. MYC. REL. ERBA.
Tumour Suppressor Genes:RB1. P53.
Other Major Tumour Suppressor Genes.
APC. BRCA1. NF1. VHL. WT1.
Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs).
Apoptosis: Tumour Suppressor Genes and Apoptosis.
DNA Repair.
Angiogenesis and Metastasis: Angiogenesis.
Angiogenic Promoters.
Angiogenic Inhibitors.
Metastasis: Correlations with Gene Expression.
Cadherins.
The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM).
Integrins.
CD44.
Matrix Metalloproteinases (MMPS).
Tissue Inhibitors of Metalloproteinases (TIMPs).
Cysteine and Aspartic Proteinases and Heparanase.
NME1 and NME2.
The Multi-step Nature of Cancer: Cervical Carcinoma.
Colorectal Carcinoma.
Breast Carcinoma.
Prostate Carcinoma.
Renal Cell Carcinoma.
Lung Carcinoma.
Lymphomas.
Chronic Myeloid Leukemia.
Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.
Tumour Suppressor Gene Therapy.
Cytokine Gene Therapy and Tumour Vaccination.
Virally Directed Enzyme Prodrug Therapy (VDEPT).
Antibody-directed Therapy.
Tables:
Oncogenes Transduced by Retroviruses.
Oncogenes Activated by Retroviral Insertion.
Oncogenes at Chromosomal Translocations.
Tumour Suppressor Genes Detected in Human Tumours.
Functions of Oncoproteins.
Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.
The Oncogenes:
ABL. AKT1andAKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1andETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1andFRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1andTHRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2andWNT3. YES1.
Tumour Suppressor Genes:
APCandMCC. BRCA1andBRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBPandMLHL. NF1andNF2. P53, PTC.
The Retinoblastoma Gene (RB1). TGFBR1andTGFBR2. VHL; WT1.
Cyclin-dependent Kinase Inhibitors:
INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2.
INK4C
andINK4D. KIP1. KIP2. WAF1.
DNA Tumour Viruses:
Human Papillomaviruses.
Epstein-Barr Virus.
Subject Index.