The Origins Of Depression: Current Concepts And Approaches: Report Of The Dahlem Workshop On The Origins Of Depression: Curren by S.A. CheckleyThe Origins Of Depression: Current Concepts And Approaches: Report Of The Dahlem Workshop On The Origins Of Depression: Curren by S.A. Checkley

The Origins Of Depression: Current Concepts And Approaches: Report Of The Dahlem Workshop On The…

byS.A. Checkley, H. Katschnig, W.z. Potter

Paperback | November 23, 2011

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3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de­ pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu­ mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex­ plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco­ logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields.
Title:The Origins Of Depression: Current Concepts And Approaches: Report Of The Dahlem Workshop On The…Format:PaperbackDimensions:474 pages, 22.9 × 15.2 × 0.01 inPublished:November 23, 2011Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642691315

ISBN - 13:9783642691317

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Table of Contents

The Scope of Depression.- The Epidemiology of Bipolar and Nonbipolar Depression: Rates and Risks.- Depression and Affective Disorder in Later Life.- Gender and Depression.- Recent Life Events and Depression.- Vulnerability to Depression: The Lack of Social Support Does Not Cause Depression.- Stress, Conflict, and Depression.- Separation Models and Depression.- Learned Helplessness - An Animal Model Revisited.- Neurobiologic Dimensions of Depression and Mania.- Current Status of Genetic Research in Affective Disorders.- Neuroendocrine Function in Depression.- Opioid Systems and the Regulation of Mood: Possible Significance in Depression?.- Neurophysiologic Studies of Depression: State of the Art.- Chronobiology of Depression.- New Research Techniques for Studying the Functional Anatomy of Depression.- Depression and Altered Neurotransmission - States, Traits, and Interactions.- Pharmacological Models of Depression.- Heuristically Important Mood-altering Drugs.- Mode of Action of Antidepressant Drugs - Primary Effects.- Mode of Action of Antidepressant Agents and ECT - Adaptive Changes After Subchronic Treatment.- Risk Factors Group Report.- Animal Models Group Report.- Functional Indices of Biological Disturbance Group Report.- Neurotransmission Group Report.- List of Participants.- Author Index.