The Pigmentary System: Physiology and Pathophysiology

Hardcover | March 1, 1998

EditorJames J. Nordlund, Raymond E. Boissy, Vincent J. Hearing

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Our knowledge about the function of the melanocyte has expanded beyond boundaries not previously imagined. The melanocyte is no longer considered merely a factory for the production of the pigment melanin. Old data do not contradict the new but must be reinterpreted in light of modern conceptsof molecular and cellular biology, enzymology, biochemistry, chemistry, and physics. Diseases of the pigmentary system must be understood in terms of modern science. The editors, each with special knowledge of the pigmentary system, have combined their expertise and talents to produce a book thatwill serve as the ultimate resource for the study of all aspects of pigment cell biology. There is no comprehensive, scholarly reference available which compiles both old and new data into a single source. This book fills that void. There are monographs to assist dermatologists caring forindividuals with disorders of pigmentation, and textbooks with an introductory chapter on the physiology of pigmentation and a clinical chapter on the disorders manifested by common abnormalities of the pigmentary system. These resources continue to be invaluable, however they are written for aspecific type and level of audience. This volume is encyclopedic in scope, so that the biologist, chemist, cosmetic scientist, and clinician, whether novice or sophisticated expert, can peruse any section of the book with confidence that it contains most of the worlds knowledge on pigmentation,including historical work. The bibliographies are also prepared to be as comprehensive and all-inclusive as possible. The first part of the book brings together the molecular and cellular biology, biochemistry, chemistry, physics, and physiology of the normal melanocyte as known in the 1990s. Thesecond part continues this theme, presenting a comprehensive discussion of most disorders of pigmentation described to date. Information about pathophysiology, treatment and other clinical data is included. The goal of the editors is to provide the ultimate reference for practicing physicians whocare for patients with the rarest or most common disorders of pigmentation, the laboratory scientist studying disease in order to help the study of basic processes which affect the pigmentary system, and the cosmetic scientist who seeks comprehensive information on the pharmacopoeia available fortreating pigmentary disorders. All specialists interested in some aspect of the pigmentary system can seek current answers to questions related to their work.

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From the Publisher

Our knowledge about the function of the melanocyte has expanded beyond boundaries not previously imagined. The melanocyte is no longer considered merely a factory for the production of the pigment melanin. Old data do not contradict the new but must be reinterpreted in light of modern conceptsof molecular and cellular biology, enzymolo...

James Nordlund is the Founding President of the PASPCR (Pan American Society for Pigment Cell Research), and a member of the Council of International Federations of Pigment Cell Societies.

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Format:HardcoverDimensions:1106 pages, 9.29 × 13.9 × 2.91 inPublished:March 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195098617

ISBN - 13:9780195098617

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Table of Contents

41. Metabolic, Nutritional and Endocrine Disorders42. Chemical, Pharmacologic and Physical Agents Causing Hypomelanoses43. Infectious Hypomelanoses44. Inflammatory Hypomelanoses45. Neoplastic Hypomelanoses46. Miscellaneous Hypomelanoses: Disorders Characterized by Depigmentation47. Miscellaneous Hypomelanoses: Disorders Characterized by Hypopigmentation48. Miscellaneous Hypomelanoses: Disorders Characterized by Extracutaneous Loss of Pigmentation49. Hypopigmentation without HypomelanosisSection 7: Disorders of Hyperpigmentation50. Genetic Epidermal Syndromes: Disorders Characterized by Generalized Hyperpigmentation51. Genetic Epidermal Syndromes: Disorders Characterized by Reticulated Hyperpigmentation52. Genetic Epidermal Syndromes: Disorders Characterized by Cafe au Lait Macules53. Genetic Epidermal Syndromes: Disorders Characterized by Lentigines54. Genetic Epidermal Syndromes: Disorders Characterized by Localized Hyperpigmentation55. Genetic Epidermal Syndromes: Disorders of Hyperpigmentation and Premature Aging56. Congenital Epidermal Hypermelanoses57. Acquired Epidermal Hypermelanoses58. Acquired and Congenital Dermal Hypermelanoses59. Mixed Epidermal and Dermal Hypermelanoses60. Drug Induced or Related Pigmentation61. The Melanocyte System of the Nails and its Disorders62. Rare Benign NeoplasmSection 8: Treatment of Pigmentary Disorders63. Topical Treatment of Pigmentary Disorders64. Phototherapy Pigmentary Disorders65. Sunscreens and Cosmetics66. Surgical Treatment of Pigmentary Disorders67. Laser Treatment of Pigmentary DisordersPart I: THE PHYSIOLOGY OF THE PIGMENTARY SYSTEMSection 1: Historical and Comparative Perspectives of the Pigment System1. A History of the Science of Pigmentation2. Comparative Anatomy and Physiology of Pigment Cells in Nonmammalian TissuesSection 2: The Morphology, Distribution and Biology of the Pigment Cell3. General Biology of Mammalian Pigmentation4. Extracutaneous Melanotcytes5. Regulation of Melanoblast Migration and Differentiation6. Biogenesis of Melanosomes7. Melanosomal Translocation and Transfer8. Human Pigmentation and Regulation9. Melanocyte Interactions in the Skin10. Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes11. Aging, Replicative Senescence and the Differentiated Function of the Melanocyte12. Advances in Long Term Maintenance of Normal Human Melanocytes in Culture13. Advances in Immortalization of Cultured Melanocytes and Melanoblasts14. Advances in Melanogenic Assays and Subcellular Fractionation15. Melanocyte Stimulating Hormone (MSH) and the MSH ReceptorSection 3: The Molecular Biology of the Pigment Cell16. Molecular Approach to the Study of Pigment Cells17. Piebaldism, Waardenburg Syndrome, and Related Genetic Disorders - Molecular and Genetic Aspects18. Anatomy of Pigment Cell Genes Acting at the Cellular Level19. Anatomy of Pigment Cell Genes Acting at the Subcellular Level20. Genetic Regulation of the Pigment Cell21. Advances in Transgenic Animal Models22. Advances in In Vitro Gene Expression23. Advances in Gene MappingSection 4: Chemistry and Physics of Melanin and Enzymology of Melanin Synthesis24. The Chemistry of Melanins and Related Metabolites25. The Physical Properties of Melanins26. The Photobiology of the Tanning Response27. The Toxicology and Pharmacology of Melanins28. The Enzymology of Melanogenesis29. Mechanisms of Inhibition of Melanin Pigmentation30. The Regulation of Melanin Formation31. Advances in Chemical Analysis of Melanins32. Advances in Physical Analysis of Melanins33. Advances in Enzymatic Analysis of MelanogenesisPart II: THE PATHOPHYSIOLOGY OF THE PIGMENTARY SYSTEMSection 5: An Overview of Human Skin Color and its Disorders34. The Normal Color of Human Skin35. Mechanisms that Cause Abnormal Skin ColorSection 6: Disorders of Hypopigmentation and Depigmentation36. Genetic Hypomelanoses: Disorders Characterized by Congenital Depigmentation37. Genetic Hypomelanoses: Disorders Characterized by Acquired Depigmentation38. Genetic Hypomelanoses: Disorders Characterized by Generalized Hypomelanosis39. Genetic Hypomelanoses: Disorders Characterized by Locilized Hypomelanosis40. Genetic Hypomelanoses: Disorders Characterized by Hypopigmentation of the Hair

Editorial Reviews

"This is a comprehensive textbook on pigmentation. The editors, together with more than 100 contributors, integrated virtually all current knowledge of the pigmentary system into a volume encyclopedic in scope."--Archives of Dermatology