The Practice Of Medicinal Chemistry

Hardcover | August 31, 2015

byCamille Georges WermuthEditorDavid Aldous, Pierre Raboisson

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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

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From the Publisher

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest t...

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Cent...
Format:HardcoverDimensions:902 pages, 9.41 × 7.24 × 0.98 inPublished:August 31, 2015Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0124172059

ISBN - 13:9780124172050

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Table of Contents

Section 1 General Aspects of Medicinal Chemistry

Section 2 Lead Compound Discovery Strategies

Section 3 Primary Exploration of Structure-Activity Relationships

Section 4 Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships

Section 5 Spatial Organization, Receptor Mapping and Molecular Modeling

Section 6 Chemical Modifications Influencing the Pharmacokinetic Properties

Section 7 Pharmaceutical and Chemical Means to Solubility and Formulation Problems

Editorial Reviews

"Having favorably reviewed the first edition, I still highly recommend this third edition to all chemists who are involved in the drug discovery process."
- John L. Neumeyer, Harvard Medical School, in JOURNAL OF MEDICINAL CHEMISTRY from the American Chemical Society