The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics by Bryan L. RothThe Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics by Bryan L. Roth

The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics

EditorBryan L. Roth

Paperback | November 9, 2010

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A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Title:The Serotonin Receptors: From Molecular Pharmacology to Human TherapeuticsFormat:PaperbackDimensions:636 pagesPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617376477

ISBN - 13:9781617376474

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Table of Contents

Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin ReceptorsWesley K. Kroeze and Bryan L. RothStructure and Function Reveal Insights in the Pharmacology of 5-HT Receptor SubtypesRichard B. Westkaemper and Bryan L. RothPolymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure: Functional and Pathological Implications,Marilyn A. Davies, Chiao-ying Chang, and Bryan L. RothStrategies for the Development of Selective Serotonergic AgentsRichard A. Glennon5-HT Receptor Signal Transduction PathwaysJohn R. Raymond, Justin H. Turner, Andrew K. Gelasco, Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur, and Maria N. GarnovskayaAgonist-Directed Trafficking of 5-HT Receptor-Mediated Signal TransductionKelly A. Berg and William P. ClarkeIdentification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins: A Proteomic ApproachJoël Bockaert, Carine Bécamel, Lara Joubert, Sophie Gavarini, Aline Dumuis, and Philippe Marin5-HT Receptor-Associated Proteins (FRAPs): Relevance for Targeting, Trafficking, and Signal TransductionZongqi Xia, Douglas J. Sheffler, and Bryan L. RothCellular and Subcellular Localization of Serotonin Receptors in the Central Nervous SystemLaurent Descarries, Virginia Cornea-Hébert, and Mustapha RiadChemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian BrainGuadalupe Mengod, M. Teresa Vilaró, Roser Cortés, Juan F. López-Giménez, Andreu Raurich, and José M. PalaciosModulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D ReceptorsPau Celada, Albert Adell, and Francesc ArtigasElectrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug ActionsEvelyn K. Lambe and George K. AghajanianThe Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining PharmaceuticalsVincent Setola and Bryan L. RothThe 5-HT3 ReceptorAndrew J. Thompson, Li Zhang, and Sarah C. R. Lummis5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for DementiaFrank Lezoualc'h and Magali BerthouzeElectrophysiological Properties of Gas-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7)Rodrigo Andrade5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in SchizophreniaRudy Schreiber, Andrew Sleight, and Marie Woolley5-HT7 Receptors as Favorable Pharmacological Targets for Drug DiscoveryPeter B. Hedlund and J. Gregor SutcliffeSerotonin System Gene Knockouts: A Story of Mice With Implications for ManMiles Berger and Laurence H. TecottEffects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and NeurotransmissionAnita J. Bechtholt and Irwin LuckiIndex

Editorial Reviews

From the reviews:"This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. . As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. . Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. . is a good, comprehensive set of reviews. . overall, it is a valuable book." (Eugene A Davidson, Doody's Review Service, February, 2007)