The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis by Edward J. MassaroThe Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis by Edward J. Massaro

The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis

EditorEdward J. Massaro, John M. Rogers

Paperback | November 5, 2010

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A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.
Title:The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and HomeostasisFormat:PaperbackDimensions:446 pages, 10 × 7.01 × 0.07 inPublished:November 5, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:161737427X

ISBN - 13:9781617374272

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Table of Contents

I. Chondrogenesis, Chondrocytes, and CartilageMolecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal ChondrogenesisRocky S. TuanChondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein SignalingLillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki NonakaRegulation of Chondrocyte DifferentiationAndreia M. Ionescu, M. Hicham Drissi, and Regis J. O'KeefeContinuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient MiceShu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard KarsentyMolecular Biology and Biosynthesis of CollagensJohanna MyllyharjuMechanotransduction Pathways in CartilageQian ChenII. Control of Skeletal DevelopmentMolecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD ComplexMarie Kmita, Denis Duboule, and József ZákányControl of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog SignalingRenee Hackenmiller, Catherine Degnin, and Jan ChristianFGF4 and Skeletal MorphogenesisValerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken MuneokaRetinoid Signaling and Skeletal DevelopmentAndrea D. Weston and T. Michael UnderhillRetinoids and Indian Hedgehog Orchestrate Long Bone DevelopmentMaurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki KoyamaIII. Osteoblastic Cell DifferentiationSynergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell DifferentiationJohn C. Lee and Lee-Chuan C. YehBone Morphogenic Proteins, Osteoblast Differentiation, and Cell Survival During OsteogenesisCun-Yu WangOsteoclast DifferentiationSakamuri V. Reddy and G. David RoodmanIV. Bone Induction, Growth, and RemodelingSoluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of BoneUgo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, and Louise RentonPerichondrial and Periosteal Regulation of Endochondral GrowthDana L. Di Nino and Thomas F. LinsenmayerComputer Simulations of Cancellous Bone RemodelingJacqueline C. van der Linden, Harrie Weinans, and Jan A. N. VerhaarEffects of Microgravity on Skeletal Remodeling and Bone CellsPierre J. MarieV. Bone MineralizationQuantitative Analyses of the Development of Different Hard TissuesSiegfried Arnold, Hans J. Höhling, and Ulrich PlateFetal Mineral Homeostasis and Skeletal MineralizationChristopher S. KovacsControl of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin DJohannes P. T. M. van Leeuwen, Marjolein van Driel, and Hulbert A. P. PolsVI. Skeletal DysmorphologyRole of Pax3 and PDGF-a Receptor in Skeletal Morphogenesis and Facial CleftingSimon J. ConwayGenetics of Achondroplasia and HypochondroplasiaGiedre GrigelionieneEffects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing RatMichael G. Narotsky, Nathalie Wéry, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard, Françoise Gofflot, and Robert J. KavlockToxicant-Induced Lumbar and Cervical Ribs in RodentsJohn M. Rogers, R. Woodrow Setzer, and Neil ChernoffExperimental Skeletal Dysmorphology: Risk Assessment IssuesRochelle W. Tyl, Melissa C. Marr, and Christina B. MyersIndex

Editorial Reviews

"...a valuable book...Every substantial biomedical library should have this book." -Doody's Health Sciences Book Review Journal"Very detailed, clinical and laden with biological terminology, which makes the preface a must for new readers." -E-STREAMS"Authoritative and up-to-date... a cutting-edge survey of diverse critical issues in bone biology." - Clinical Laboratory International