The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Paperback | July 1, 2010

EditorKlaus Olgaard, Justin Silver, Isidro B. Salusky

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Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineralmetabolism. This has lead to the development of new treatment strategies and agents. This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts.

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Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineralmetabolism. This has lead to the development ...

Klaus Olgaard is Professor of Nephrology and Internal Medicine at the University of Copenhagen and at Department of Nephrology, Rigshospitalet, Copenhagen, Denmark. His scientific interests are basic and clinical research in nephrology-endocrinology and uremia, especially related to physiology and pathophysiology of calcium, phosphoru...

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Format:PaperbackDimensions:592 pages, 9.21 × 6.14 × 0.01 inPublished:July 1, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199559171

ISBN - 13:9780199559176

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Table of Contents

1. Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD)2. New aspects of normal bone biology3. Osteocytes and mineral metabolism4. Calcium-sensing receptors (CaSRs) in kidney, bone and vessels5. Regulation of parathyroid hormone biosynthesis and gene expression6. Abnormal parathyroid gland function in CKD7. PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor8. Vitamin D metabolism and action in CKD9. Growth factors and cytokines in renal bone disease10. Bone histomorphometry in renal osteodystrophy11. The spectrum of renal osteodystrophy and vascular calcifications in uremia12. Imaging of the skeleton and the joints in CKD13. Non-invasive assessment of vascular calcification and arterial stiffness14. Osteopenia in uremia15. Acidosis and renal bone disease16. Dialysis-associated amyloidosis17. Pathogenesis of vascular calcification: experimental studies18. Clinical consequences of arterial calcifications and soft-tissue calcifications in Chronic Kidney Disease19. Clinical management of vascular and soft tissue calcifications in Chronic Kidney Disease patients20. The role of the skeleton in the pathogenesis of vascular calcification in the Chronic Kidney Disease-Mineral Bone Disorder21. Klotho: bone, kidney, vascular calcifications, and the ageing process22. Physiology and pathology of calcium and magnesium transport23. Phosphatonins in health and disease24. FGF-23 in renal failure25. New vitamin D analogs for chronic kidney disease patients26. Calcimimetics and calcilytics in the treatment of chronic kidney disease-mineral and bone disorder27. Medical therapy in chronic kidney disease28. Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children29. Bone disease in renal transplant recipients30. Imaging and intervention of parathyroid hyperplasia31. Surgical management of secondary hyperparathyroidism32. Morbidity and mortality related to disturbances in mineral metabolism in CKD