The SV40 Replicon Model for Analysis of Anticancer Drugs

Other | May 1, 1996

bySnapka, Robert M., Robert M. Snapka

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This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments.

Key Features
* Presents unique advantages of SV40 as an experimental system for the study of classes of anticancer drugs
* Details new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication
* Provides details to help the reader design and interpret similar experiments

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This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system ...

Dr. Snapka is an associate professor of Radiology at The Ohio State University, teaching courses in Radiation Biology, DNA Tumor Viruses, Drug Resistance, and Genetic Instability. Dr. Snapka earned his B.S. in Biology and M.S. in Chemistry at North Texas State University. He earned his Ph.D. at the University of California, Irvine and ...

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Format:OtherDimensions:193 pages, 1 × 1 × 1 inPublished:May 1, 1996Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080550185

ISBN - 13:9780080550183

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Table of Contents

R.M. Snapka, Papovavirus Models for Mammalian Replicons.
R.M. Snapka, Analysis of SV40 DNA Replication Intermediates.
R.M. Snapka, Catastrophic Failure of DNA Replication Forks: Structural and RecombinationalPathways.
R.M. Snapka and E.F. Yamasaki, Topoisomerase II and the Termination of DNA Replication.
R.M. Snapka, DNA Damaging Agents.
R.M. Snapka, C.A. Ferrar, N.-J. Sun, and J.M. Cassady, Drug Discovery and Evaluation with SV40.
L.H. Malkas, Simian Virus 40 (SV40)in VitroDNA Replication: A Potential Model for Studying Anticancer Drug Action.
R.M. Snapka and P.A. Permana, SV40 Circular Oligomer Series: Normal and Abnormal DNA Replication.
Subject Index.