The Synapse: Function, Plasticity, and Neurotrophism

Hardcover | December 1, 1994

byMotoy Kuno

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The synapse not only provides a bridge from one nerve cell to the next; its function can be modified by experience, making it important for learning and memory. In this first accessible overview of the synapse, Kuno provides a review of current concepts in neurobiology with specific reference to synaptic plasticity, neurotransmission and neurotrophism. These areas have been advanced dramatically by the application of molecular biology techniques, and The Synapse provides a much needed synthesis of these advances. Kuno incorporates all the latest thinking and current research together with a brief historical overview of research in the field,providing an invaluable text for both the student and the researcher.

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The synapse not only provides a bridge from one nerve cell to the next; its function can be modified by experience, making it important for learning and memory. In this first accessible overview of the synapse, Kuno provides a review of current concepts in neurobiology with specific reference to synaptic plasticity, neurotransmission a...

Motoy Kuno, Professor Emeritus of Physiology, Kyoto University Faculty of Medicine.
Format:HardcoverDimensions:262 pages, 9.69 × 9.69 × 0.01 inPublished:December 1, 1994Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198546874

ISBN - 13:9780198546870

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Table of Contents

Part I: The Synapse1. Historical perspective of the synapse1.1. Contiguity versus continuity at synaptic sites1.2. Chemical versus electrical synaptic transmission1.3. Synaptic vesicles and transmitter quanta1.4. Receptors for the synaptic transmitter2. The role of calcium in transmitter release2.1. Calcium is an essential co-factor for transmitter release2.2. The diversity of calcium channels3. How transmitter release is triggered3.1. Fusion of synaptic vesicles with the nerve terminal membrane3.2. The origin of transmitter quanta4. Ionotropic receptors mediate fast synaptic responses4.1. The molecular structure of ionotropic receptors4.2. How ionotropic receptors function4.3. The structure-function correlation in ionotropic receptors5. Metabotropic receptors mediate slow synaptic responses5.1. Molecular structure of metabotropic receptors5.2. Signal transduction by metabotropic receptors5.3. Modulation of synaptic functionPart II: Plasticity6. Historical perspective of neuronal plasticity6.1. Early concepts of neuronal plasticity6.2. Use and disuse effects on synaptic function6.3. Hobbian synapses6.4. Long-term potentiation7. Functional plasticity at synapses7.1. Substrates involved in plasticity at peripheral synapses7.2. Long-term plasticity at central synapses8. Molecular castades in learning8.1. Molecular changes associated with learning8.2. Gene expression associated with neuronal plasticity9. Morphological plasticity at synapses9.1. How nerve fibres sprout9.2. Morphological correlates of functional synaptic plasticityPart III: Neurotrophism10. Historical perspective of neurotrophism10.1. Early concepts of neurotrophic function10.2. Inductive influence of the motor neurone on muscle10.3. Trophic influence from muscle on the motor neurone10.4. The discovery of neurotrophic factors11. Neurotrophic factors responsible for neuronal survival11.1. The definition of neurotrophic function11.2. The neurotrophins11.3. Ciliary neurotrophic factor11.4. Motoneuronal trophic factors12. Neurotrophic regulation at developing synapses12.1. Developmental regulation of transmitter receptors12.2. Transmitter choice during development13. Target-dependence of the neuronal state13.1. Regulation of neuronal properties by the target13.2. Target-dependence of neuronal survival

Editorial Reviews

`No attempt is made to be all inclusive in scope or detail, rather a thoughtful glimpse is provided to stimulate our thinking on future research. The author has succeeded in bringing together evidence from multidisciplinary approaches to the study of the synapse with the aim of communication,summarization, and provoking comment.'Douglas E. Brenneman, National Institutes of Health, Bethesda, Journal of Chemical Neuroanatomy 12 (1997)