The Synaptic Organization of the Brain

Paperback | November 17, 2003

EditorGordon M. Shepherd

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It is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies of synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years.In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of geneproducts? Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with anincreasing range of behavioral and gene-targeting methods. Leading experts in the best understood brain regions bring together the molecular, anatomical, functional, and behavioral data in authoritative integrated accounts. The chapters are organized in the same format, covering the neural elements,synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, membrane properties, dendritic properties, and with a final section on how the circuits mediate specific behaviors. The uniform framework for each chapter enables the authors to higlight the principles that arecommon to all regions, as well as the adaptations unique to each, thus serving as a model for understanding the neural basis of behavior.

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It is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies of synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years.In this fifth edition, the results of the mo...

Gordon M. Shepherd is at Yale University School of Medicine.

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Format:PaperbackDimensions:736 pages, 6.3 × 9.09 × 1.5 inPublished:November 17, 2003Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019515956X

ISBN - 13:9780195159561

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Table of Contents

1. Gordon M. Shepherd: Introduction to Synaptic Circuits2. David A. McCormick: Membrane Properties and Neurotransmitter Actions3. Robert E. Burke: Spinal Cord: Ventral Horn4. Eric D. Young and Donata Oertel: Cochlear Nucleus5. Gordon M. Shepherd, Wei R. Chen and Charles A. Greer: Olfactory Bulb6. Peter Sterling and Jonathan B. Demb: Retina7. Rodolfo R. Llinas, Kerry D. Walton and Eric J. Lang: Cerebellum8. S. Murray Sherman and R.W. Guillery: Thalamus9. Charles J. Wilson: Basal Ganglia10. Kevin R. Neville and Lewis B. Haberly: Olfactory Cortex11. Daniel Johnston and David G. Amaral: Hippocampus12. Rodney Douglas, Henry Markram and Kevin Martin: Neocortex

Editorial Reviews

"An excellent introduction into the principles of synaptic organization of various brain regions."--Neuroscience