The Telomere by David KiplingThe Telomere by David Kipling

The Telomere

byDavid KiplingAs told byDavid Kipling

Paperback | April 30, 1999

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Telomeres are specialised structures at ends of linear chromosomes. They are involved in a wide range of genetic phenomena ranging from novel biochemistry to a potential role in human ageing and cancer. This book covers a number of diverse subjects including: the role of telomeres in nuclearorganisation; telomere DNA sequence and unusual structures formed by telomeric sequences in vitro; replication of telomere sequences by telomerase and how this relates to various DNA sequence features; proteins that bind or interact with telomeres; the role of telomeres in programmed and spontaneouschromosome breakage; recent speculation on the relationship between telomere loss, aging and cancer; telomere position effects on replication and transcription; human telomere structure, genome analysis and genetic disease. This is the first book of its kind to cover this exciting and rapidly expanding field of molecular biology and genetics. It will provide an invaluable teaching tool, and introduction to the subject for newcomers to the field, and also act as an invaluable reference for establishedresearchers.
David Kipling is at MRC Human Genetics Unit, Edinburgh.
Title:The TelomereFormat:PaperbackDimensions:218 pages, 9.21 × 6.14 × 0.51 inPublished:April 30, 1999Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199636001

ISBN - 13:9780199636006

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Table of Contents

Introduction1. The cytology of the telomere2. Telomere structure3. Telomerase4. Telomere proteins5. Genome rearrangements and telomeres6. Human telomere loss, ageing, and cancer7. Chromatin structure and position effects8. Structure and maintenance of Drosophila telomeres9. Telomeres and mammalian genome analysis

Editorial Reviews

`an excellent little book ... a very timely introduction to the telomere mystery ... Thoroughly recommended and cheap at the price in paperback.'Eric Reeve, University of Edinburgh, Genetical Research, Vol. 67 - 1996