The Theory of Response-Adaptive Randomization in Clinical Trials

August 18, 2006|
The Theory of Response-Adaptive Randomization in Clinical Trials by Feifang Hu
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Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice

The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures.

This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including:

  • How does response-adaptive randomization affect power?
  • Can standard inferential tests be applied following response-adaptive randomization?
  • What is the effect of delayed response?
  • Which procedure is most appropriate and how can "most appropriate" be quantified?
  • How can heterogeneity of the patient population be incorporated?
  • Can response-adaptive randomization be performed with more than two treatments or with continuous responses?

The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes:

  • The relationship between power and response-adaptive randomization
  • The general result for determining asymptotically best procedures
  • Procedures based on urn models
  • Procedures based on sequential estimation
  • Implications for the practice of clinical trials

Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.

FEIFANG HU, PhD, is Associate Professor in the Department of Statistics at the University of Virginia. He is the recipient of numerous grants, honors, and awards. His research interests include biostatistics, applied probability and statistical inference, and resampling methods. He has authored over forty refereed articles. WILLIAM F....
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Title:The Theory of Response-Adaptive Randomization in Clinical TrialsFormat:HardcoverProduct dimensions:232 pages, 9.49 X 6.36 X 0.76 inShipping dimensions:232 pages, 9.49 X 6.36 X 0.76 inPublished:August 18, 2006Publisher:WileyLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0471653969

ISBN - 13:9780471653967

Appropriate for ages: All ages

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