The Zebrafish: Disease Models And Chemical Screens by H. William Detrich, IiiThe Zebrafish: Disease Models And Chemical Screens by H. William Detrich, Iii

The Zebrafish: Disease Models And Chemical Screens

byH. William Detrich, IiiEditorLeonard Zon, Monte Westerfield

Hardcover | January 27, 2017

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The Zebrafish: Disease Models and Chemical Screens, Fourth Edition, the latest volume in theMethods in Cell Biologyseries, looks at methods for analyzing genetics, genomics, and transcriptomics of zebrafish. Chapters cover such topics as gene-trap mutagenesis, genetic screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, developmental epigenetics, and the zebrafish interactome.



  • Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies
  • Includes chapters written by experts in the field
  • Contains cutting-edge material on the topics discussed
Professor of Biochemistry and Marine Biology at Northeastern University, promoted 1996. Joined Northeastern faculty in 1987. Previously a faculty member in Dept. of Biochemistry at the University of Mississippi Medical Center, 1983-1987.Principal Investigator in the U.S. Antarctic Program since 1984. Twelve field seasons "on the ice" s...
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Title:The Zebrafish: Disease Models And Chemical ScreensFormat:HardcoverDimensions:746 pages, 9.41 × 7.24 × 0.98 inPublished:January 27, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128034734

ISBN - 13:9780128034736

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Table of Contents

Part I: Adipose Tissue 1. In vivo imaging and quantification of regional adiposity in zebrafish

Part II: Innate and Adaptive Immune Systems 2. Innate immune cells and bacterial infection in zebrafish 3. Best practices for germ-free derivation and gnotobiotic zebrafish husbandry 4. Infectious disease models in zebrafish 5. Live imaging the earliest host innate immune response to preneoplastic cells using a zebrafish inducible KalTA4-ERT2/UAS system 6. Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells

Part III: Blood and Lymph 7. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis 8. Studying disorders of vertebrate iron and heme metabolism using zebrafish 9. The lymphatic vasculature revisited new developments in the zebrafish

Part IV: Visceral Organs 10. Modeling intestinal disorders using zebrafish 11. Analysis of pancreatic disease in zebrafish

Part V: Musculoskeletal System 12. Using the zebrafish to understand tendon development and repair 13. Small teleost fish provide new insights into human skeletal diseases 14. Muscular dystrophy modeling in zebrafish

Part VI: Central and Sensory Nervous Systems 15. Analysis of myelinated axon formation in zebrafish 16. Zebrafish models of human eye and inner ear diseases

Part VII: Cancer 17. A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response 18. Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling 19. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma 20. Zebrafish models of leukemia 21. Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain

Part VIII: Transplantation 22. Transplantation in zebrafish

Part IX: Chemical Screening 23. Chemical screening in zebrafish for novel biological and therapeutic discovery