Therapeutic Antibodies by Yuti ChernajovskyTherapeutic Antibodies by Yuti Chernajovsky

Therapeutic Antibodies

EditorYuti Chernajovsky, Ahuva Nissim

Paperback | November 17, 2010

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This essential work, edited by two researchers at London's famous Queen Mary's medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.
Title:Therapeutic AntibodiesFormat:PaperbackDimensions:392 pages, 9.25 × 6.1 × 0 inPublished:November 17, 2010Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642092306

ISBN - 13:9783642092305

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Table of Contents

Part 1: Introduction.- Historical Development of Monoclonal Antibody Therapeutics. Preclinical Safety Evaluation of Monoclonal Antibodies .- Part II: Molecular Developments in Antibody Production.- Engineering Antibodies for Stability and Efficient Folding. Human Monoclonal Antibodies from Transgenic Mice.- Part III: Antibodies to Cytokines.- Anti-TNF Antibodies: Lessons from the Past, Roadmap for the Future. Therapeutic Anti-VEGF Antibodies. Humanized Anti-human IL-6 Receptor Antibody, Tocilizumab.- Part IV: Antibodies to Cell Markers.- Anti-CD20 Monoclonal Antibody in Rheumatoid Arthritis and Systemic Lupus Erythematosus. Herceptin. The Use of CD3-Specific Antibodies in Autoimmune Diabetes: A Step Towards the Induction of Immune Tolerance in the Clinic. Monoclonal Antibody Therapy for Prostate Cancer. Anti-IgE and other Antibody Targets in Asthma.- Part V: Development of Antibody-Based Cellular and Molecular Therapies.- Cytokine, Chemokine, and Co-stimulatory Fusion Proteins for the Immunotherapy of Solid Tumors. The T-Body Approach: Redirecting T-Cells with Antibody Specificity. Intracellular Antibodies (Intrabodies) as Specific Molecules for Therapeutic Applications.