Thrombolytic Therapy for Acute Stroke by Patrick D. LydenThrombolytic Therapy for Acute Stroke by Patrick D. Lyden

Thrombolytic Therapy for Acute Stroke

EditorPatrick D. Lyden

Paperback | December 16, 2010

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This extensively revised and expanded second edition incorporates the knowledge gained from the widespread implementation of large rt-PA for acute stroke trials and demonstrates the power of the new technologies now available. The authors have included much new material on stroke-MRI and computed omogaraphy, and updated all chapters describing the background, use, and nuances of thrombolytic therapy. They present everything one needs to know for proper patient selection, the key to successful treatment. Practical how-to chapters guide the reader in treating acute stroke patients, both with and without thrombolytic therapy. New detailed practice cases that simulate making the rounds in a world-class stroke center prepare practitioners to be as ready as possible for their first case.

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Title:Thrombolytic Therapy for Acute StrokeFormat:PaperbackDimensions:392 pages, 9.02 × 5.98 × 0.68 inPublished:December 16, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375403

ISBN - 13:9781617375408

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Table of Contents

Part I: Background and Basic InvestigationsMechanisms of ThrombolysisGregory J. del Zoppo and Naohisa HosomiPathology of Cervico-Cranial Artery OcclusionLouis R. CaplanThe Ischemic Penumbra and Neuronal SalvagePatrick D. LydenPart II: Scientific Rationale and Clinical TrialsPre-Clinical Testing of Thrombolytic Therapy for Acute Ischemic StrokeSteven R. LevineCombination of Thrombolytic Therapy With NeuroprotectantsJames C. Grotta and Lise A. LabichePilot and Preliminary Studies of Thrombolytic Therapy for StrokeSteven R. Levine, E. Clarke Haley, and Patrick D. LydenIntravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large Randomized Clinical TrialsMatthew L. Flaherty, Edward C. Jauch, Rashmi U. Kothari, and Joseph P. BroderickFurther Analysis of NINDS Study: Long-Term Outcome, Subgroups, and Cost EffectivenessSusan C. Fagan, Thomas D. Kwiatkowski, and Patrick D. LydenCommunity Experience With Intravenous Thrombolysis for Acute StrokeLama Al-Khoury and Christy M. JacksonIntra-Arterial Thrombolysis in Acute Ischemic StrokeAnthony J. Furlan, Randall Higashida, Irene Katzan, Alex Abou-Chebl, and Andrew N. RussmanCombinations of Intravenous and Intra-Arterial ThrombolysisMatthew L. Flaherty and Joseph BroderickPart III: Using Thrombolysis for Acute StrokeThrombolysis in Vertebrobasilar Occulsive DiseaseLouis R. CaplanThrombolytic Therapy in Stroke PatientsPatrick D. LydenStroke Thrombolysis: The Present Guidelines and Policies for Clinical Use Should Be ChangedLouis R. CaplanHow to Run a Stroke CodeAskiel BrunoThe Impact of Computed Tomography on Acute Stroke TreatmentRüdiger von KummerUsing Magnetic Resonance Imaging to Select and Manage Patients for TreatmentPeter D. Schellinger, Chelsea S. Kidwell, and Steven WarachThe rt-PA for Acute Stroke ProtocolJohn Marler and Patrick D. LydenPart IV: Illustrative CasesIllustrative CasesIndex

Editorial Reviews

Reviews of the first edition:"...the authors succeeded very well in their intention to make a reference work that is based not only on scientific evidence but also on their own experience in the field." - Acta Neurologica Belgica"This is very much a hands on book, with much practical advice, ranging from detailed advice about the assessment and selection of patients for thrombolysis to how to set up and deliver an emergency service for stroke. The book ranges from a detailed description of the evidence from clinical trials to advice based on personal experience....proceeds to an excellent account of the early trials of thrombolysis...an excellent chapter follows on the techniques and interpretation of CT in acute stroke....the book is highly recommended as a guide to current practice for those contemplating introducing thrombolysis into their clinical practice." - Journal of Neurology, Neurosurgery, and Psychiatry"The purpose is to bring all individuals who actively manage stroke up-to-date with the current literature. The author adequately accomplishes this by doing a comprehensive review of the available research published in this field. The objectives are quite worthy and well met. . .The author has taken care of stroke patients for years and thus is a credible authority on the subject. The book covers all aspects of the clinical trials, outcomes, and current arguments in the field of thrombolysis. There is an excellent chapter that offers opinions from several stroke experts. Finally, the case presentations at the end of the book are well done and helpful. This is a nice wrap-up of the material. This is an excellent overview of current literature on thrombolysis for stroke. I would highly recommend it for anyone who manages the acute stroke patient. It is probably one of the best I have seen on the topic."-Doody's Health Sciences Book Review Journal"The authors of this fine reference book cover all aspects of thrombolytic therapy related to cerebral ischaemia. From the pathophysiology to analysis of scientific studies to clinical use, the information in these 18 chapters may be useful to any of the physicians who threat patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists....The authors provide data necessary for understanding the indications and limitations of thrombolytic therapy, so that even the practitioners unfamiliar with the subject can obtain sufficient information for evaluation of potential patients....All chapters are well referenced with up-to-date citations. In summary, the editor, Patrick D. Layden, has orchestrated the assembly of a superb book that provides a comprehensive source of information on thrombolytic therapy for acute stroke patients." - European Journal of Emergency Medicine"Co-authored by many leaders in the field of acute stroke therapy, this book represents a thorough yet concise primer on stroke thrombolysis....The strength of this book lies in its balance: it provides the reader with enough of a knowledge base to develop a good understanding of the issues surrounding stroke thrombolysis, whereas avoiding information overload. The writing is generally clear, concise, and well referenced....The chapters are accompanied with informative tables and well reproduced imaging studies. The case presentations at the end provide an excellent opportunity for the reader to take what has been learned and apply it to real patient scenarios....This book is intended for the wide range of clinicians involved in the care of acute stroke patients, including neurology residents, neurologists, neurosurgeons, emergency physicians, primary care providers, and emergency service coordinators."- Neurology, Official Journal of the American Academy of Neurology