Toll-Like Receptor Family Members and Their Ligands by Bruce BeutlerToll-Like Receptor Family Members and Their Ligands by Bruce Beutler

Toll-Like Receptor Family Members and Their Ligands

EditorBruce Beutler, Hermann Wagner

Paperback | September 18, 2011

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The innate immune system is sometimes referred to as the "primitive" immune system. Perhaps this has dissuaded immunologists from analyzing it so energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisticated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due.
Title:Toll-Like Receptor Family Members and Their LigandsFormat:PaperbackDimensions:202 pages, 9.25 × 6.1 × 0.03 inPublished:September 18, 2011Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642639755

ISBN - 13:9783642639753

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Table of Contents

Evolution of the TIR, Tolls and TLRs: Functional Inferences from Computational Biology.-Plant Disease Resistance: Commonality and Novelty in Multicellular Innate Immunity.-Superfamily Signal Transduction Pathways Activated by the IL-1 Receptor/Toll-Like Receptor.-Toll Receptors in Drosophila: A Family of Molecules Regulating Development and Immunity.-Toll-Like Receptors and Their Ligands.-Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin.-TLR4 as the Mammalian Endotoxin Sensor.-TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns.-Bacterial CpG-DNA Licenses TLR9.-MyD88 as a Bottle Neck in Toll/IL-1 Signaling.-Heat Shock Proteins as Ligands of Toll-Like Receptors.-Subject Index.