Top Drugs: Top Synthetic Routes

Paperback | May 1, 2000

byJohn Saunders

not yet rated|write a review
Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) ora screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of thebest selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, formany drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.

Pricing and Purchase Info

$31.50

Ships within 1-3 weeks
Ships free on orders over $25

From the Publisher

Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) ora screening lead as a starting point. Many ...

Dr John Saunders, Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.

other books by John Saunders

Playing Hurt: My Journey from Despair to Hope
Playing Hurt: My Journey from Despair to Hope

Hardcover|Aug 8 2017

$31.15$35.00list pricesave 11%
A History of Medieval Islam
A History of Medieval Islam

Kobo ebook|Mar 11 2002

$48.99$61.22list pricesave 19%
see all books by John Saunders
Format:PaperbackDimensions:96 pages, 9.69 × 7.44 × 0.24 inPublished:May 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198501005

ISBN - 13:9780198501008

Look for similar items by category:

Customer Reviews of Top Drugs: Top Synthetic Routes

Reviews

Extra Content

Table of Contents

1. Inhibitors of angiotensin converting enzyme as effective antihypertensive agents2. Blockade of angiotensin-II receptors3. Calcium channel blockers in the treatment of angina and hypertension4. Antagonists of histamine receptors (H2) as anti-ulcer remedies5. Proton pump inhibitors as gastric acid secretion inhibitors6. Modulation of central serotonin in the treatment of depression7. Hypnotic, anxiolytic, anticonvulsant and muscle relaxant agents: ligands for benzodiazepine receptors8. Another histamine receptor: blockers of the H1 receptor for the treatment of seasonal allergic rhinitis9. Nucleoside analogues which inhibit HIV reverse transcriptase10. Quinolones as anti-bacterial DNA gyrase inhibitors

Editorial Reviews

"This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field." -- Doody's