Top Drugs: Top Synthetic Routes by John SaundersTop Drugs: Top Synthetic Routes by John Saunders

Top Drugs: Top Synthetic Routes

byJohn Saunders

Paperback | May 1, 2000

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Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) ora screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of thebest selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, formany drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.
Dr John Saunders, Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.
Title:Top Drugs: Top Synthetic RoutesFormat:PaperbackDimensions:96 pages, 9.69 × 7.44 × 0.24 inPublished:May 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198501005

ISBN - 13:9780198501008

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Table of Contents

1. Inhibitors of angiotensin converting enzyme as effective antihypertensive agents2. Blockade of angiotensin-II receptors3. Calcium channel blockers in the treatment of angina and hypertension4. Antagonists of histamine receptors (H2) as anti-ulcer remedies5. Proton pump inhibitors as gastric acid secretion inhibitors6. Modulation of central serotonin in the treatment of depression7. Hypnotic, anxiolytic, anticonvulsant and muscle relaxant agents: ligands for benzodiazepine receptors8. Another histamine receptor: blockers of the H1 receptor for the treatment of seasonal allergic rhinitis9. Nucleoside analogues which inhibit HIV reverse transcriptase10. Quinolones as anti-bacterial DNA gyrase inhibitors

Editorial Reviews

"This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field." -- Doody's