Toxin-Induced Models of Neurological Disorders

Hardcover | July 31, 1994

EditorA.J. Nonneman, M.L. Woodruff

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This is the first evaluative discussion of the use of neurotoxins to produce animal models of Alzheimer's, Parkinson's, Huntington's and other human neurodegenerative diseases. The work also responds to criticisms of the use of animals in biomedical research by examining the utility, validity, and limitations of the models presented. An excellent resource for researchers and students in the neurosciences and environmental toxicology interested in both the practical and ethical aspects of animal research.

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This is the first evaluative discussion of the use of neurotoxins to produce animal models of Alzheimer's, Parkinson's, Huntington's and other human neurodegenerative diseases. The work also responds to criticisms of the use of animals in biomedical research by examining the utility, validity, and limitations of the models pres...

Format:HardcoverDimensions:365 pages, 9.25 × 6.1 × 0.03 inPublished:July 31, 1994Publisher:Springer US

The following ISBNs are associated with this title:

ISBN - 10:0306446146

ISBN - 13:9780306446146

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Table of Contents

Animal Models and the Implications of Their Use (A.J. Nonneman, M.L. Woodruff). Strategies for Developing Animal Models of NeurotoxicantInduced Neurodegenerative Disorders (P.R. Solomon et al.). Experimental Paradigms of Motor Neuron Degeneration (M.J. Strong, R.M. Garruto). Hydroxydopamine Lesions of Nigrostriatal Neurons as an Animal Model of Parkinson's Disease (P.J. Reading, S.B. Dunnett). MPTPTreated Mice (E. Sundstrom et al.). Behavioral Effects of MPTP Administration in the Vervet Monkey (J.R. Taylor et al.). Intranigral Iron Infusion as a Model for Parkinson's Disease (G.W. Arendash et al.). Excitotoxic Lesions of the Neostriatum as an Animal Model of Huntington's Disease (D.F. Emerich et al.). The Use of AF64A to Model Alzheimer's Disease (T.J. Walsh, K.D. Opello). Perinatal Intake of Polychlorinated Biphenyl (L.M. Juárez de Ku, L.A. Meserve). Aluminum Exposure Produces Learning and Memory Deficits (R.A. Yokel). Trimethyltin Neurotoxicity in the Rat as an Analogous Model of Alzheimer's Disease (M.L. Woodruff, R.H. Baisden). Index.