tPA for Stroke: The Story of a Controversial Drug

Hardcover | March 26, 2010

byJustin A. Zivin, John Galbraith Simmons

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Each year, nearly 700,000 people in the United States will have a stroke. A drug known as tPA can drastically reduce the long-term disability associated with stroke if it is administered within the first three hours after the event occurs. Many of those who are lucky enough to be treated withtPA have made full recoveries - to the extent that one can hardly believe they suffered a "real" stroke. Others still do not receive the drug; many suffer permanent disabilities, and many die.Authors Zivin and Simmons argue that most Americans have never heard of tPA. Why would such an effective pharmaceutical, one that has a remarkable rate of success with the third leading killer of Americans, be so disregarded? tPA for Stroke: The Story of a Controversial Drug explains the drug'sbeginnings within pharmaceutical giant Genentech, and its eventual marginalization due to a convergence of unfortunate political, fiscal, and medical circumstances. Readers will learn about an extraordinary treatment for acute stroke that they may then seek if a stroke occurs and anyone interestedin the unique process of drug development, marketing, and promotion, told from an insider's perspective, will have an interest intPA for Stroke.

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Each year, nearly 700,000 people in the United States will have a stroke. A drug known as tPA can drastically reduce the long-term disability associated with stroke if it is administered within the first three hours after the event occurs. Many of those who are lucky enough to be treated withtPA have made full recoveries - to the exten...

Justin Zivin is a Professor of Neurosciences at the University of California San Diego. He holds both MD and PhD degrees from Northwestern University, and was trained as a neurologist at the University of California San Francisco. For more than thirty years he has conducted research in acute stroke therapy both for basic science studi...
Format:HardcoverDimensions:224 pages, 9.25 × 6.12 × 0.98 inPublished:March 26, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195393929

ISBN - 13:9780195393927

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Table of Contents

To the ReaderPart One: Discovery1. Code Stroke on Market Street2. Clotbuster: The Natural History3. Dead or Alive4. Brain-OPart Two: Change, Resistance, and Transformation5. The Brain Doctors Cometh - Slowly6. What Emergency?7. Money and Brain8. Deer in the Headlights9. Call 911, 112, 15...Even 99910. Persistence of a Most Controversial Drug11. Through the Looking GlassPost-Script: The NINDS Stroke Study: A Personal StatementList of InterviewsBibliography