TRAIL

Other | July 1, 2004

byLitwack, Gerald, Gerald Litwack

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The discovery of TRAIL (TNF Related Apoptosis Inducing Ligand), also referred to as Apo-2, is in an era of intense research because TRAIL induces many cancer cells to undergo programmed cell death (apoptosis), while having no effect on normal cells. This important protein deserves extensive review at a formative time in the devlopement of our knowledge concerning its mechanism of action and the ways in which it can be used as a cancer chemotherapeutic agent. Consequently, this voume reviews the current status of research on TRAIL.

Selected Contents:
* Crystal Structure of RANK Ligand involved in bone metabolism
* Promoter of TRAIL-R2 Gene
* Monoclonal Antibodies against TRAIL
* Modulation of TRAIL signaling complex
* TRAIL in the airways
* FLIP Protein and TRAIL-Induced Apoptosis
* TRAIL and Ceramide
* TRAIL and Viral Infection
* TRAIL and Malignant Glioma

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From the Publisher

The discovery of TRAIL (TNF Related Apoptosis Inducing Ligand), also referred to as Apo-2, is in an era of intense research because TRAIL induces many cancer cells to undergo programmed cell death (apoptosis), while having no effect on normal cells. This important protein deserves extensive review at a formative time in the devlopemen...

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralys...

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Format:OtherDimensions:448 pages, 1 × 1 × 1 inPublished:July 1, 2004Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080522874

ISBN - 13:9780080522876

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