Transcription Factors and Human Disease by Gregg L. SemenzaTranscription Factors and Human Disease by Gregg L. Semenza

Transcription Factors and Human Disease

byGregg L. Semenza

Hardcover | August 1, 1998

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Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving manyof the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation ofprogenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses.Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somaticcell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are alsoexplored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.
Gregg L. Semenza is at Johns Hopkins University School of Medicine.
Title:Transcription Factors and Human DiseaseFormat:HardcoverDimensions:384 pages, 9.41 × 6.18 × 1.18 inPublished:August 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195112393

ISBN - 13:9780195112399

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Table of Contents

Part I: Transcriptional Regulation1. Gene Expression and Transcriptional Regulation2. CIS-acting Transcriptional Regulatory Elements3. Trans-acting FactorsPart II: Transcriptional Pathophysiology4. Mutations in Cis-acting Transcriptional Regulatory Elements5. Mutations in Genes Encoding Transcription Factors:The Nuclear Receptor Superfamily6. Other Zinc-Finger Proteins: WT1 and GLI37. PAX Proteins8. bHLH Proteins9. Homeodomain Proteins10. HMG Domain Proteins11. POU Domain Proteins12. Other Transcriptional Factor Families13. Co-activators14. General Transcription Factors15. Somatic Cell Genetic Disease: Cancer16. Epigenetic Disease: Teratogenesis

Editorial Reviews

"The most useful chapters of the book are those...organized by transcription factor family....Students of human biology will find this material accessible, useful, and remarkably thorough...."--CELL