Transcriptional and Translational Regulation of Stem Cells by Gary HimeTranscriptional and Translational Regulation of Stem Cells by Gary Hime

Transcriptional and Translational Regulation of Stem Cells

byGary HimeEditorHelen Abud

Hardcover | June 6, 2013

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This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes - achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different stem cell examples - embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
Title:Transcriptional and Translational Regulation of Stem CellsFormat:HardcoverDimensions:371 pagesPublished:June 6, 2013Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9400766203

ISBN - 13:9789400766204

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Table of Contents

1. The stem cell state; Gary R. Hime and Helen E. Abud

2. Induction of pluripotency; Corey Heffernan, Jun Liu, Huseyin Sumer, Luis F. Malaver-Ortega,Rajneesh Verma, Edmund Carvalhoand Paul J. Verma

Model stem cell systems

(A) Invertebrate

3. Germline stem cells and their regulation in the nematodeCaenorhabditis elegans; Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter and Judith Kimble

4. Transcriptional and post-transcriptional regulation ofDrosophilagermline stem cells and their differentiating progeny; Helen White-Cooper and Simona Caporilli

5. Stem cells in theDrosophiladigestive system; Xiankun Zeng, Chhavi Chauhan, and Steven X. Hou

6. Mechanisms of Asymmetric Progenitor Divisions in theDrosophilaCentral Nervous System; Rita Sousa-Nunes and W. Gregory Somers

(B) Vertebrate

7. Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells; Cathryn Hogarth

8. Transcriptional Regulation and Specification of Neural Stem Cells;Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate and Ann M. Turnley

9. Transcriptional Control of Epidermal Stem Cells;Briana Lee and Xing Dai

10. Regulation of intestinal stem cells by Wnt and Notch signalling; Katja Horvay and Helen E. Abud

11. Transcriptional regulation of haematopoietic stem cells; Adam C. Wilkinson and Berthold Göttgens

12. Regulation of mesenchymal stem cell differentiation; David Cook and Paul Genever

Molecular families implicated in stem cell regulation

13. The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations; Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime and Nicole A. Siddall

14. JAK-STAT signalling in stem cells; Rachel R. Stine and Erika L. Matunis

15. Myc in Stem Cell Behaviour: insights from Drosophila; Leonie M. Quinn, Julie Secombe and Gary R. Hime

16. The Role of Nuclear Receptors in Embryonic Stem Cells; Qin Wang and Austin J. Cooney

17. Epigenetic regulation of stem cells; Anton Wutz

18. Regulation of stem cell populations by microRNAs; Julie Mathieu and Hannele Ruohola-Baker

19. Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches; Jordane Malaterre, Lloyd Pereira and Robert G. Ramsay