Transgenic and Knockout Models of Neuropsychiatric Disorders by Gene S. FischTransgenic and Knockout Models of Neuropsychiatric Disorders by Gene S. Fisch

Transgenic and Knockout Models of Neuropsychiatric Disorders

EditorGene S. Fisch

Paperback | November 9, 2010

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In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.
Title:Transgenic and Knockout Models of Neuropsychiatric DisordersFormat:PaperbackDimensions:308 pages, 9.02 × 5.98 × 0 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617376078

ISBN - 13:9781617376078

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Table of Contents

Introduction and OverviewTransgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and AssessmentGene S. FischTransgenic Mouse Models and Human Psychiatric DiseaseJonathan FlintTransgenic and Knockout Mouse Models: The Problem of LanguageLinda J. Hayes and Diana DelgadoIf Only They Could Talk: Genetic Mouse Models for Psychiatric DisordersTrevor Humby and Lawrence WilkinsonTransgenic and Knockout Models of Neurocognitive DysfunctionSpinocerebellar Ataxia Type 1: Lessons From Modeling a Movement Disease in MiceHarry T. OrrMouse Models of Hereditary Mental RetardationHans Welzl, Patrizia D'Adamo, David P. Wolfer, and Hans-Peter LippHow Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?Simon E. FisherAnimal Models of Autism: Proposed Behavioral Paradigms and Biological StudiesThomas Bourgeron, Stéphane Jamain, and Sylvie GranonTransgenic and Knockout Models of Neuropsychiatric DysfunctionGenetic Mouse Models of Psychiatric Disorders: Advantages, Limitations, and ChallengesJoseph A. Gogos and Maria KarayiorgouAnimal Models of PsychosisStephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller, and John MastropaoloAnimal Models of Anxiety: The Ethological PerspectiveRobert Gerlai, Robert Blanchard, and Caroline BlanchardModeling Human Anxiety and Depression in Mutant MiceAndrew Holmes and John F. CryanMutant Mouse Models of Bipolar Disorder: Are There Any?Anneloes Dirks, Lucianne Groenink, and Berend OlivierIndex

Editorial Reviews

Aus den Rezensionen:". Das vorliegende Buch versucht, den aktuellen Stand einer faszinierenden Entwicklung festzuhalten, und beleuchtet durch Aufsätze von international anerkannten Autoren verschiedene Aspekte des Einsatzes von transgenen Tiermodellen bei neuropsychiatrischen Krankheitsbildern. Der erste einführende Teil des Buches gibt einen Überblick über Geschichte und die Untersuchung von Tiermodellen bei neuropsychiatrischen Fragestellungen. . Insgesamt stellt dieses Buch eine überaus interessante und anregende Lektüre . und könnte dabei wichtige Anregungen zur translationalen Umsetzung von Forschungsinhalten . vermitteln."(H. H. Jung, in: Schweizer Archiv für Neurologie und Psychiatrie, 2007, Vol. 158, Issue 2, S. 91)