Translational Toxicology: Defining A New Therapeutic Discipline by Claude L. Hughes

Translational Toxicology: Defining A New Therapeutic Discipline

byClaude L. HughesEditorMichael D. Waters

Hardcover | April 7, 2016

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Bringing together a distinguished interdisciplinary team of contributors,this volume provides a comprehensive exploration of translational toxicology-a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice.

Translational Toxicology: Defining a New Therapeutic Disciplineis an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Claude L. Hughes ,M.D., Ph.D. is Executive Director in the Therapeutic Science & Strategy Unit within Quintiles Inc. He is board-certified in Obstetrics & Gynecology and Reproductive Endocrinology and Infertility. He is a Consulting Professor in the Department of Obstetrics & Gynecology, Duke University Medical Center and a...
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Title:Translational Toxicology: Defining A New Therapeutic DisciplineFormat:HardcoverDimensions:380 pages, 23.5 X 15.5 X 0.25 inPublished:April 7, 2016Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319274473

ISBN - 13:9783319274478

Appropriate for ages: All ages

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From the Author

Bringing together a distinguished interdisciplinary team of contributors,this volume provides a comprehensive exploration of translational toxicology-a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice.Translational Toxicology: Defining a New Therapeutic Disciplineis an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Table of Contents

I.Introduction .- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline.- The Role of Toxicokinetics and Toxicodynamics in Developmental and Translational Toxicology.-II.Toxicant Modes of Action and Biomarkers .- Mutational Effects.- Ligand-Mediated Toxicology: Characterization and Translational Prospects.- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype.- Fetal Imaging and Effects of Exposures on Growth and Function.- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics .- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey.- The "Toxic" Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations.- The Role of Environmental Exposures in Preterm Birth.- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions.- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.