Treatment of Acute Leukemias: New Directions for Clinical Research by Ching-Hon PuiTreatment of Acute Leukemias: New Directions for Clinical Research by Ching-Hon Pui

Treatment of Acute Leukemias: New Directions for Clinical Research

EditorChing-Hon Pui

Paperback | November 19, 2010

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International experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy.
Title:Treatment of Acute Leukemias: New Directions for Clinical ResearchFormat:PaperbackDimensions:577 pages, 10.98 × 8.27 × 0.03 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372129

ISBN - 13:9781617372124

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Table of Contents

Part I: Diagnosis, Classification, and PrognosisClassification of Acute Leukemias: Perspective 1Wolf-Dieter Ludwig, Torsten Haferlach, and Claudia SchochClassification of Acute Leukemias: Perspective 2Frederick G. BehmPart II: Chemotherapeutic StrategiesA. Infant LeukemiasBiology and Treatment of Infant Leukemias: Perspective 1Rob PietersBiology and Treatment of Acute Leukemias in Infants: Perspective 2Gregory H. ReamanB. Childhood Acute Lymphoblastic LeukemiaTreatment of Childhood Acute Lymphoblastic LeukemiaMartin Schrappe and Martin StanullaTreatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium PerspectiveLewis B. Silverman and Stephen E. SallanC. Acute Lymphoblastic Leukemia in Adolescents and Young AdultsTreatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future DirectionsSima Jeha and Hagop M. KantarjianTreatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children's Cancer Group TrialsJames NachmanD. Acute Lymphoblastic Leukemia in AdultsTreatment of Adult Acute Lymphoblastic Leukemia: Perspective 1Spero R. Cataland and Richard A. LarsonTreatment of Adult Acute Lymphoblastic Leukemia: Perspective 2Dieter Hoelzer and Nicola GökbugetE. Central Nervous System Therapy for Acute Lymphoblastic LeukemiaCentral Nervous System-Directed Therapy for Acute Lymphoblastic LeukemiaJudith M. ChessellsDiagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic LeukemiaAnjo J. P. VeermanF. Relapsed Acute Lymphoblastic LeukemiaTreatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1Helmut Gadner, Georg Mann, and Christina PetersTreatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2Günter Henze and Arend von StackelbergG. B-Cell Acute Lymphoblastic LeukemiaTreatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1Catherine PatteTreatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2John T. SandlundH. Acute Myeloid Leukemia in ChildrenTreatment of Acute Myeloid Leukemia in ChildrenUrsula CreutzigTreatment of Childhood Acute Myeloid LeukemiaDavid M. Loeb and Robert J. ArceciI. Acute Myeloid Leukemia in AdultsTherapy of Acute Myeloid Leukemia in AdultsBob LöwenbergTreatment of Adult Acute Myelogenous LeukemiaRicardo T. Spielberger and Stephen J. FormanJ. Acute Promyelocytic LeukemiaAcute Promyelocytic Leukemia: Perspective 1Zhu Chen and Zhen-Yi WangAcute Promyelocytic Leukemia: Perspective 2Francesco Lo Coco, Giuseppe Avvisati, and Franco MandelliK. Childhood Leukemias in Underprivileged CountriesTreatment of Childhood Leukemias in Underprivileged CountriesBharat Agarwal and Rashmi DalviHow to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged PopulationsGiuseppe Masera and Andrea BiondiPart III: Antileukemic DrugsA. High-Dose Methotrexate in Childhood Acute Lymphoblastic LeukemiaRationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic LeukemiaTimothy L. Brenner and William E. EvansRole of Methotrexate in the Treatment of Acute Lymphoblastic LeukemiaBruce M. Camitta and Barton A. KamenB. AsparaginaseAsparaginaseBarbara L. Asselin and Joanne KurtzbergAsparaginase TreatmentCarmelo RizzariC. Antipurines in Childhood Acute Lymphoblastic LeukemiaAntipurines in Childhood Acute Lymphoblastic LeukemiaPaul S. Gaynon and Peter C. AdamsonAntipurinesLynne Lennard and John S. LilleymanD. EpipodophyllotoxinsEtoposide in Acute Leukemias: Therapeutic and Pharmacokinetic ConsiderationsMary V. RellingEtoposide and Teniposide: Clinical Applications with a Focus on LeukemiaMalcolm A. SmithPart IV: Hematopoietic Stem Cell TransplantationHematopoietic Stem Cell Transplantation: Perspective 1Frederick R. AppelbaumHematopoietic Stem Cell Transplantation: Perspective 2Vilmarie Rodriguez and Helen E. HeslopPart V: Biologic TreatmentsA. Hematopoietic Growth FactorsHematopoietic Growth Factors in Patients with Acute LeukemiaCharles A. SchifferHematopoietic Growth Factor Treatment in LeukemiaKarl WelteB. ImmunotherapyImmunotherapy of LeukemiaKenneth B. DeSantes and Paul M. SondelTherapy of Acute Leukemia with Monoclonal Antibodies and ImmunoconjugatesEric L. Sievers, Dana C. Matthews, and Irwin D. BernsteinPart VI: Drug ResistanceDrug Resistance in Acute LeukemiasJean-Piere Marie and Ollivier LegrandDrug Resistance in Acute LeukemiaYaddanapudi Ravindranath and Robert J. ArceciPart VII: Minimal Residual DiseaseMinimal Residual DiseaseDario CampanaMolecular Monitoring of Minimal Residual DiseaseGiovanni Cazzaniga and Andrea BiondiIndex

Editorial Reviews

"...This book offers the best approach to the presentation of problems related to the treatment of the acute leukemias that I know of. The idea of having different groups of investigators give their views on the topics and the emphasis on future directions make it an important contribution to the study of leukemia. Treatment of Acute Leukemias should be read by both adult and pediatric hematologists and oncologists, and it should be required reading for trainees in these disciplines. Dr. Pui, who has already made major contributions through his own work, has added greatly to the future of the field by organizing and editing this impressive book." -New England Journal of Medicine"...comprehensive and up to date. This is one of the best books produced in recent years on the diagnosis and management of the acute leukaemias." - European Journal of Haematology