TRP Channels in Drug Discovery: Volume II by Arpad SzallasiTRP Channels in Drug Discovery: Volume II by Arpad Szallasi

TRP Channels in Drug Discovery: Volume II

EditorArpad Szallasi, Tamás Bíró

Hardcover | October 2, 2012

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Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders.  Written for the Methods in Pharmacology and ToxicologyT series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Title:TRP Channels in Drug Discovery: Volume IIFormat:HardcoverDimensions:504 pages, 10 × 7.01 × 0.1 inPublished:October 2, 2012Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1627030948

ISBN - 13:9781627030946

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Table of Contents

Part I: TRPs and Cardiovascular Disease  1. TRPs to Cardiovascular Disease             José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, and Mohamed Trebak 2. Anemic Zebrafish Models of Cardiomyopathy            Xiaojing Sun and Xiaolei Xu 3. Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function            Yan Ma, Yung-Wui Tjong, and Xiaoqiang Yao 4. Atherosclerosis Models with Cell-Mediated Calcification            Beili Zhu 5. Models of Hypertension and Blood Pressure Recording             Luciana Aparecida Campos and Ovidiu Constantin Baltatu 6. Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling            Wei Zhang and Mohamed Trebak Part II: TRPs and the Brain 7. TRP Channels in the Brain            Antonio Reboreda Prieto 8. Investigation of the Possible Role of TRP Channels in Schizophrenia            Loris A. Chahl 9. Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish             Amanda Decker and Robert Cornell 10. A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents             Caitlin J. Riebe and Carsten T. Wotjak 11. Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory             Jennifer L. McGuire, Jennifer L. Coyner, and Luke R. Johnson 12. Chick Anxiety-Depression Screening Model             Stephen W. White and Kenneth J. Sufka 13. A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat             Ryan C. Turner, Alisa S. Elliott, Jason D. Huber, and Charles L. Rosen 14. Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies             Koji Shibasaki 15. Methods in Neuronal Growth Cone Biology             Robert J. Gasperini and Lisa Foa Part III: TRPs and Skin 16. Transient Receptor Potential Channels and Pruritus            Heike Benecke, Janine Wäring, Tobias Lotts, and Sonja Ständer 17. Skin Sensitivity Studies             Laurent Misery 18. Hair Follicle Culture             Michael P. Philpott Part IV: TRPs and Metabolic Disorders 19. Animal Models for Type 1 Diabetes            Anish Suri and Matteo Levisetti 20. Type 2 Diabetes Models            Dorte X. Gram 21. Using Diet to Induce Metabolic Disease in Rodents            Angela M. Gajda, Michael A. Pellizzon, and Matthew R. Ricci  22. Rodent Models to Evaluate Anti-Obesity Drugs             Sharon Cheetham and Helen Jackson Part V: TRPs: Colitis, Cancer, Thermosensation, and Musculoskeletal Disorders 23. Experimental Colitis Models            Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington, and L. Ashley Blackshaw 24. Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis             V'yacheslav Lehen'kyi, Sergii Khalimonchyk, Albin Pourtier, Maylis Raphaël, and Natalia Prevarskaya 25. Methods to Study Thermonociception in Rodents            Kata Bölcskei 26. Methods for the Assessment of Heat Perception in Humans            Michael F. Crutchlow and Joel D. Greenspan 27. Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain             Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson 28. Animal Models of Muscular Dystrophy            Yuko Iwata and Shigeo Wakabayashi            Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I.