Tumor Prevention and Genetics by Hans-j SennTumor Prevention and Genetics by Hans-j Senn

Tumor Prevention and Genetics

byHans-j SennEditorRudolf Morant

Paperback | October 8, 2012

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Hans-Jorg Senn H.-J. Senn (<_29_20_center20_for20_tumor20_detection20_and20_prevention2c_20_rorschacherstr.20_1502c_20_ch-900620_st.20_gallen2c_20_switzerland20_clinical20_oncology20_has20_centered20_mainly20_on20_developing20_new20_strategies20_and20_a20_multitude20_of20_new20_drugs20_for20_fighting20_relapsing20_and20_progressive20_cancer20_during20_the20_last20_two20_decades.20_furthermore2c_20_it20_has20_done20_this20_with20_respectable20_success20_in20_quite20_a20_number20_of20_neoplastic20_diseases20_such20_as20_acute20_leukemias20_and20_sarcomas20_in20_pediatric20_patients20_and20_certain20_types20_of20_aggressive20_lymphomas2c_20_as20_well20_as20_sec2ad_20_lected20_solid20_tumors20_such20_as20_testicular20_cancer20_and20_choriocarcinoma20_in20_adult20_age.20_curatively20_intended20_adjuvant20_chemo-and20_endocrine-therapies20_of20_several20_22_main20_killers22_20_among20_prevalent20_cancer20_types2c_20_especially20_breast20_and20_colon20_canc2ad_20_cer2c_20_have20_also20_become20_successful20_and20_health-politically20_meaningful20_therapeutic20_targets20_5b_12c_20_25d_.20_however2c_20_the20_net20_gain20_in20_22_cure22_20_of20_these20_28_mostly20_pharmacologic29_20_therapeuc2ad_20_tic20_approaches20_has20_to20_be20_realistically20_judged20_as20_having20_a20_moderate20_impact20_on20_the20_cancer20_problem20_as20_a20_whole2c_20_and20_the20_mortality20_rate20_of20_the20_most20_frequent20_tuc2ad_20_mor20_types2c_20_which20_are20_prevalent20_in20_adult20_life2c_20_has20_with20_very20_few20_exceptions20_not20_been20_substantially20_decreased20_over20_the20_past20_two20_to20_three20_decades.20_increasingly2c_20_health20_politicians2c_20_epidemiologists2c_20_and20_medical20_journal20_editors20_are20_asking20_for20_alternative20_strategies20_of20_lowering20_cancer20_incidence20_and20_increasing20_survival2c_20_ventilating20_new20_and20_hitherto20_mostly20_neglected20_areas20_of20_research20_such20_as20_pric2ad_20_mary20_and20_secondary20_cancer20_prevention. center="" for="" tumor="" detection="" and="" _prevention2c_="" rorschacherstr.="" _1502c_="" ch-9006="" st.="" _gallen2c_="" switzerland="" clinical="" oncology="" has="" centered="" mainly="" on="" developing="" new="" strategies="" a="" multitude="" of="" drugs="" fighting="" relapsing="" progressive="" cancer="" during="" the="" last="" two="" decades.="" _furthermore2c_="" it="" done="" this="" with="" respectable="" success="" in="" quite="" number="" neoplastic="" diseases="" such="" as="" acute="" leukemias="" sarcomas="" pediatric="" patients="" certain="" types="" aggressive="" _lymphomas2c_="" well="" _sec2ad_="" lected="" solid="" tumors="" testicular="" choriocarcinoma="" adult="" age.="" curatively="" intended="" adjuvant="" chemo-and="" endocrine-therapies="" several="" _22_main="" _killers22_="" among="" prevalent="" _types2c_="" especially="" breast="" colon="" _canc2ad_="" _cer2c_="" have="" also="" become="" successful="" health-politically="" meaningful="" therapeutic="" targets="" _5b_12c_="" _25d_.="" _however2c_="" net="" gain="" _22_cure22_="" these="" _28_mostly="" _pharmacologic29_="" _therapeuc2ad_="" tic="" approaches="" to="" be="" realistically="" judged="" having="" moderate="" impact="" problem="" _whole2c_="" mortality="" rate="" most="" frequent="" _tuc2ad_="" mor="" which="" are="" _life2c_="" very="" few="" exceptions="" not="" been="" substantially="" decreased="" over="" past="" three="" _increasingly2c_="" health="" _politicians2c_="" _epidemiologists2c_="" medical="" journal="" editors="" asking="" alternative="" lowering="" incidence="" increasing="" _survival2c_="" ventilating="" hitherto="" mostly="" neglected="" areas="" research="" _pric2ad_="" mary="" secondary="">
Title:Tumor Prevention and GeneticsFormat:PaperbackDimensions:266 pagesPublished:October 8, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642628923

ISBN - 13:9783642628924

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Table of Contents

1 Latest News in Cancer Genetics.- Genetic Susceptibility, Predicting Risk and Preventing Cancer.- Novel Approaches to Identify Low Penetrance Cancer Susceptibility Genes Using Mouse Models.- 2 Assessing New Cancer Susceptibility Genes.- Development of Novel Selective Cell Ablation in the Mammary Gland and Brain to Study Cell-Cell Interactions and Chemoprevention.- Mouse Skin as a Model for Cancer Chemoprevention by Nonsteroidal Anti-Inflammatory Drugs Friedrich Marks, Gerhard Fürstenberger; Gitta Neufang,.- Preclinical Models for Chemoprevention of Colon Cancer.- New Cancer Biomarkers Deriving from the NCI Early Detection Research.- 3 Update in Chemoprevention of Breast Cancer.- Tamoxifen's Impact as a Preventive Agent in Clinical Practice and an Update on the STAR Trial.- Aromatase Inhibitors in Prevention - Data from the ATAC (Arimidex, Tamoxifen Alone orin Combination) Trial and the Design of IBIS-II (The Second International Breast Cancer Intervention Study).- HRT Opposed by Low Dose Tamoxifen (HOT Study). Rationale and Design.- 4 Secondary Prevention of Breast Cancer: The Mammography Controversy.- Is Mammography Screening for Breast Cancer Really Not Justifiable?.- How Reliable is the Evidence for Screening Mammography?.- Political Interpretation of Scientific Evidence - Case Study of Breast Cancer Screening Policies Around the World.- 5 Chemoprevention of Skin and Lung Cancer.- Skin Cancer Chemoprevention: Strategies to Save our Skin.- Chemoprevention of Non-Melanoma Skin Cancer: Experience with a Polyphenol from Green Tea.- Chemoprevention of Lung Cancer: New Directions.- Key Issues in Lung Cancer Chemoprevention Trials of New Agents.- 6 Prevention and Screening of Prostate Cancer.- Prevention of Prostate Cancer.- Clinical Models for Testing Chemopreventative Agents in Prostate Cancer and Overview of SELECT: The Selenium and Vitamin ECancer Prevention Trial.- Problems with Prostate Specific Antigen Screening: A Critical Review.- 7 Prevention and Screening of Colorectal Cancer.- Genetic Predisposition as a Basis for Chemoprevention, Surgical and Other Interventions in Colorectal Cancer.- Fecal Occult Blood (FOB) Screening - Trial Evidence, Practice and Beyond Gad Rennert.- Is FOB-Screening Really the Answer for Lowering Mortality in Colorectal Cancer?.- Summary and Conclusions.