Tumor Targeting in Cancer Therapy by Michel PagéTumor Targeting in Cancer Therapy by Michel Pagé

Tumor Targeting in Cancer Therapy

EditorMichel Pagé

Paperback | November 19, 2010

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In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.
Title:Tumor Targeting in Cancer TherapyFormat:PaperbackDimensions:473 pages, 10 × 7.01 × 0.07 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:161737251X

ISBN - 13:9781617372513

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Table of Contents

Part I. A ReviewThe Current Status of Tumor Targeting: A ReviewTarunendu GhoseClinical Applications of Targeted TherapeuticsTarunendu GhosePart II. Targeting Tumors with Drug Antibody ConjugatesTargeting the CD22 Receptor with RNA Damaging AgentsHuaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville, and Susanna M. RybakThe Development of Liposomes for Enhanced Delivery of Chemotherapeutics to TumorsPaul Tardi, Ludger Ickenstein, Marcel Bally, and Lawrence MayerOvercoming Multiple Drug Resistance with Anti-Pgp CarrierBrigitte Pagé and Michel PagéTargeting with Transferrin, Mandip SinghSynthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In VitroJairo Jaime Correa and Michel PagéThe Use of Drug-Monoclonal Antibody Conjugates for the Treatment of CancerGeoffrey A. Pietersz and Ian F. C. McKenziePart III. Targeting Tumors with AntibodiesTargeting Vascular Endothelium with AntibodiesPrzemek Twardowski and Kim MargolinTargeting B-Cell Non-Hodgkin's Lymphoma with Monoclonal AntibodiesChristian Buske and W. HiddemannFrom Bench to Bedside: Development of Rituximab (Rituxan ®), A Monoclonal Antibody for the Therapy of Non-Hodgkin's LymphomaRoland NewmanMylotarg: The First Antibody-Targeted Chemotherapy AgentPhilip R. Hamann and Mark S. BergerPart IV. Targeting Tumors with Radioimmunoconjugates188Rhenium-Labeled Trisuccin-DCh2HuCC49 as a Radioimmunotherapy Model in Nude MiceAhmad Safavy and Donald J. BuchsbaumPart V. Targeting Tumors with ImmunotoxinsGeneral Approach for Targeting ToxinsManish Monga, Richard A. Messman, and Edward A. SausvilleAntibody-Toxin Conjugates: Chemistry of Coupling and PurificationSilvana Canevari, Maria Ines Colnaghi, Luigi Cattel, and Franco DosioShiga-Like Toxins as Targeted Anticancer AgentsPaul LaPointe and Jean GariépyPart VI. Targeting Tumors with Antibody-Enzyme Conjugates (ADEPT)Antibody-Directed Enzyme Prodrug Therapy with Carboxypeptidase G2: Clinical StudiesKenneth D. BagshawePart VII. Photodynamic TherapyPhotodynamic Therapy: Targeting Cancer Cells with Photosensitizer-BioconjugatesCynthia M. Allen, Wesley M. Sharman, and Johan E. van LierTumor Targeting Using PEG-m-THPC for Photodynamic Therapy in a Rat Ovarian-Cancer ModelRené HornungPart VIII. Targeting Tumors with Magnetic DrugsTargeting Tumors with Magnetic DrugsAndreas S. Lübbe, Christian Bergemann, and Christoph AlexiouPart IX. Principles and Techniques in TargetingInternalization of AntibodiesJairo Jaime CorreaBioconjugation and BiodistributionFrancesco M. Veronese and Paulo CalicetiPrinciples of Antitumor Targeting of Cytotoxic DrugsGene M. DubowchikTargeting by Antibody or Ligand: Which Is Better?Douglas A. LappIndex

Editorial Reviews

"This book stands out among many books with similar titles in that it deals with topics in a sequence that best describes the fundamentals and applications of drug targeting....Each chapter of the book was well balanced to have both basic and clinical aspects. This book is highly recommended for all graduate students, researchers, and clinicians who are involved in the antibody-based drug targeting." -- Pharmaceutical Research"Tumor Targeting in Cancer Therapy represents an outstanding work, describing both experimental and clinical application of antibodies for targeting tumors." -Neoplasma