Tumour Angiogenesis

Hardcover | June 1, 1997

EditorRoy Bicknell, Claire E. Lewis, Napoleone Ferrara

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Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

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From the Publisher

Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prost...

Dr Roy Bicknell, Imperial Cancer Research Fund, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxon OX3 9DU, Tel (1865) 222421, Fax (1865) 222431, email: bicknelr.@icrf.icnet.uk; Dr C E Lewis, Senior Lecturer, Department of Pathology, University of Sheffield Medical School, Royal Hallamshir...
Format:HardcoverDimensions:396 pages, 9.69 × 7.44 × 1.1 inPublished:June 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198549377

ISBN - 13:9780198549376

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Table of Contents

1. Bicknell, Lewis and Ferrara: Introduction2. Fan and Polverini: In Vivo Models of Angiogenesis3. Bicknell: Mechanistic Studies of Tumour Angiogenesis4. Gasparini: Prognostic and Predictive Value of Intra-tumoral Microvessel Density in Human Solid Tumours5. Jain: Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection and Treatment6. Chaplin, Trotter, and Dougherty: Microregional Tumour Blood Flow: Heterogeneity and Therapeutic Significance7. Keshet, Stein, Neeman: Mechanisms of Stress-Induced Angiogenesis in Tumours8. Leek, Lewis, and Harris: The role of Macrophages in Tumour Angiogenesis9. Rastinejad and Bouck: Oncogenes and Tumour Suppressor Genes in the Regulation of Angiogenesis10. Lewis and Balkwill: The role of cytokines in angiogenesis11. Bikfalvi, Klein, and Pintucci: The Role of Proteases in Angiogenesis12. Vlodavsky, Miao, Ishai-Michaeli, Benezra, Levy, Bar-Shavit and Peretz: Involvement of the Extracellular Matrix, Heparan Sulfate Proteoglycans and Heparan Sulfate Degrading Enzymes in Angiogenesis and Metastasis13. Rooney, Kumar, Ponting and Kumar: The Role of Collagens and Proteoglycans in Tumour Angiogenesis14. Hisrt and Flitney: The Physiological Importance and Therapeutic Potential of Nitric Oxide in the Tumour-associated Vasculature15. Bobik, Agrotis and Little: Vascular Derived Growth Factors: Potential Role in the Development of the Tumour Vasculature16. Ferrara: The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth17. Christofori: The Role of Fibroblast Growth Factors in Tumour Progression and Angiogenesis18. Madri and Sankar: The Biphasic Effects of Transforming Growth Factor in Angiogenesis19. Moghaddam, Choudhuri and Bicknell: Thymidine phosphorylase/platelet-derived endothelial cell growth factor an angiogenc enzyme20. Fajardo and Allison: Tumor Necrosis Factor and Angiogenesis21. Schulte and Wellstein: Pleiotrophin and Related Molecules22. Spisni and Tomasi: The Involvement of prostanoids in angiogenesis23. Bicknell and Holmgren: The Inhibition of tumour angiogenesis24. Pepper, Tacchini-Cottier, Sabapathy, Montesano and Wagner: Endothelial Cells Transformed by Polyomavirus Middle-T Oncogene: A Model for Haemangiomas and Other Vascular Tumours25. Young and Laskey: Development of the Embryonic Vascular System26. Derbyshire and Thorpe: Targeting the Tumour Endothelium Using Specific Antibodies27. Bicknell: Vascular Targeting of anti-cancer gene therapy

Editorial Reviews

`'This is an interesting book...''Cellular and Molecular Biology, June vol.44/No.4, 1998.