Tumour Viruses by Joanna ParishTumour Viruses by Joanna Parish

Tumour Viruses

Guest editorJoanna Parish

Hardcover | January 12, 2016

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Current worldwide estimates suggest that approxiamtely 11% of all cancers are caused by viral infections. At present, there are eight viruses that have a strong association with cancer development namely, human papillomavirus, Epstein-Barr virus, Kaposi’s sarcoma-associated herpes virus, human T-cell lymphotrophic virus type I, Merkel cell polyomavirus, hepatitis B and C viruses and human immunodeficiency virus. Some of these viruses and associated cancers, such as human papillomavirus and cervical cancer, are well studied and the causal link between infection and cancer development is established. However, the involvement of these known oncogenic viruses in cancer development at other body sites is not well understood and further study of these viruses continues to highlight novel mechanisms of cellular transformation. Other cancer-associated viruses are only recently discovered, such as Merkel cell polyomavirus, and further work is required to formally prove their role in cancer development. In this Special Issue, we seek to explore novel mechanisms of cellular transformation by oncogenic viruses, the role of viral infection in cancer development in understudied body sites and the potential role of novel viral pathogens in cancer development.

Title:Tumour VirusesFormat:HardcoverProduct dimensions:470 pages, 9.61 × 6.69 × 1.44 inShipping dimensions:9.61 × 6.69 × 1.44 inPublished:January 12, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038421510

ISBN - 13:9783038421511


Table of Contents

Human Viruses and CancerThe Role of Merkel Cell Polyomavirus and Other Human Polyomaviruses in EmergingHallmarks of CancerHuman Papillomaviruses; Epithelial Tropisms, and the Development of NeoplasiaHuman Papillomavirus and Tonsillar and Base of Tongue CancerInteraction of Human Tumor Viruses with Host Cell Surface Receptors and Cell EntryPapillomavirus Infectious Pathways: A Comparison of SystemsHigh-Risk Human Papillomavirus Targets Crossroads in Immune SignalingModulation of DNA Damage and Repair Pathways by Human Tumour VirusesThe Role of the DNA Damage Response throughout the Papillomavirus Life CycleActivation of DNA Damage Response Pathways during Lytic Replication of KSHVTargeting CTCF to Control Virus Gene Expression: A Common Theme amongst DiverseDNA VirusesRegulation of the Wnt/????-Catenin Signaling Pathway by Human Papillomavirus E6 and E7OncoproteinsThe Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to MalignancyHPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour CellsRecent Progress in Therapeutic Treatments and Screening Strategies for the Prevention andTreatment of HPV-Associated Head and Neck CancerThe Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in CervicalCancer Cells and Its Perturbation by RNA AptamersMechanisms of Cancer Cell Killing by the Adenovirus E4orf4 ProteinImpact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular GeneExpressionRole of Host MicroRNAs in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis