Tyrosine Phosphoprotein Phosphatases

Paperback | February 1, 1998

byBarry Goldstein

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Tyrosine phosphoprotein phosphatases (PTPases) are found ubiquitously in cytosolic and particulate fractions of cells. They are unique in terms of their substrate sensitivity, neutral pH optimum, resistance to EDTA, and inhibition by low concentrations of zinc or vandanate. PTPases exert bothpositive and negative effects on a number of metabolic and signal transduction pathways. This volume explores the sequence, structure, and biochemical properties of PTPases, regulation of PTPase expression, substrate preferences and catalytic mechanisms, physiology, covalent modification,modification by chemical agents and proteolysis, and interactions with other proteins, peptides, and macromolecules. There is an extensive bibliography to assist the reader in further research.

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Tyrosine phosphoprotein phosphatases (PTPases) are found ubiquitously in cytosolic and particulate fractions of cells. They are unique in terms of their substrate sensitivity, neutral pH optimum, resistance to EDTA, and inhibition by low concentrations of zinc or vandanate. PTPases exert bothpositive and negative effects on a number of...

Dr Barry Goldstein, Endocrinology/Rm 349, Alumni Hall, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19017-6799, USA

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Format:PaperbackDimensions:272 pages, 9.69 × 9.69 × 0.07 inPublished:February 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198502478

ISBN - 13:9780198502470

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Table of Contents

1. Introduction2. Protein-tyrosine phosphatases3. Patterns and Regulation of PTPase Expression4. Biochemical Studies and PTPase Catalytic Activity5. Covalent Modification of PTPases6. Modification of PTPases with other Proteins, Peptides and Macromolecules7. Interactions of PTPases with other Proteins, Peptides and Macromolecules8. The Physiology of PTPases9. Bibliography

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