Uncultivated Microorganisms by Slava S. EpsteinUncultivated Microorganisms by Slava S. Epstein

Uncultivated Microorganisms

EditorSlava S. Epstein

Paperback | November 29, 2011

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The number of existing microbial species may be in the millions, but only a few thousand have been isolated in pure culture and described. The principal reason for this tremendous disparity is that, mysteriously, over 99% of all environmental microorganisms refuse to grow in the laboratory. The phenomenon of microbial uncultivability has been recognized as one of the main challenges for basic and applied microbiology, and finding a way to access this uncultivated microbial majority may change many aspects of biology and biotechnology as we know them today.This volume describes the discovery of the phenomenon, the current hypotheses on its physiological and molecular nature, state-of-the-art approaches to "outsmarting" the uncultivated microorganisms, and the importance of the uncultivated microbial majority in medicine and biotechnology. It reveals the hidden universe of uncultivated microorganisms, their unparalleled diversity and enormous potential for application.
Title:Uncultivated MicroorganismsFormat:PaperbackDimensions:218 pages, 9.25 × 6.1 × 0 inPublished:November 29, 2011Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642242588

ISBN - 13:9783642242588

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Table of Contents

S S Epstein: The long history of a puzzling phenomenon; J Bunge: Statistical estimation of uncultivated microbial diversity; M L Sogin, J A Huber: Unveiling microbial diversity through advances in DNA sequencing; T Gentry, Z He, J Zhou: Detection and Characterization of Uncultivated Microorganisms using Microarrays; A Boetius: Measuring geochemical activities of uncultivated microorganisms; M Podar, M Keller, P Hugenholtz: Insights into novel biodiversity using single-cell genome amplification approaches; T Schmidt, A Konopka: Slow growing microbes: ecological strategies and consequences for cultivation; R Colwell: Viable but not cultivable microorganisms; S S Epstein: General model of microbial uncultivability; V Miao, J Davies: Metagenomic approaches to drug discovery; K Lewis: Persisters, biofilms, and the problem of uncultivability; K H Nealson: Taking the concept to the limit: uncultivable bacteria and astrobiology.