Vaccine Adjuvants by Charles J. HackettVaccine Adjuvants by Charles J. Hackett

Vaccine Adjuvants

EditorCharles J. Hackett, Donald A. Harn Jr

Paperback | December 9, 2010

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A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.

Details & Specs

Title:Vaccine AdjuvantsFormat:PaperbackDimensions:296 pages, 9.02 × 5.98 × 0 inPublished:December 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372404

ISBN - 13:9781617372407

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Table of Contents

Microbial Pathogenesis and the Discovery of Toll-Like Receptor FunctionBruce BeutlerDendritic Cells: Targets for Immune Modulation by Microbes and ImmunologistsBali Pulendran, Anshu Agrawal, Stephanie Dillon, and Sudhanshu AgrawalAchieving Transcriptional Specificity in NF-kB-Dependent Inflammatory Gene ExpressionGioacchino NatoliAdjuvants and the Initiation of T-Cell ResponsesMatthew F. Mescher, Julie M. Curtsinger, and Marc JenkinsMechanism for Recognition of CpG DNAKiyoshi Takeda, Hiroaki Hemmi, and Shizuo AkiraCpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic VaccinesArthur M. Krieg and Heather L. DavisModified Bacterial ToxinsEd C. Lavelle, Olive Leavy, and Kingston H. G. MillsGlycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan ParasitesRicardo T. Gazzinelli, Catherine Ropert, Igor C. Almeida, João S. Silva, and Marco A. CamposThe Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein AntigensMitsuhiro Okano, Kazunori Nishizaki, Akram Da'dara, Paul Thomas, Michele Carter, and Donald A. Harn, Jr.Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide: Molecular Basis and Clinical PotentialGeorge M. BahrEffect of QS-21 on Innate and Adaptive Immune ResponsesCharlotte Read Kensil, Gui Liu, Christine Anderson, and James StoreyMonophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and ImmunomodulatorsJory Baldridge, Kent Myers, David Johnson, David Persing, Christopher Cluff, and Robert HershbergMicroparticles and DNA VaccinesKimberly Denis-Mize, Manmohan Singh, Derek T. O'Hagan, Jeffrey B. Ulmer, and John J. DonnellyIndex

Editorial Reviews

From the reviews:"This book describes in detail major advances in vaccine adjuvant discovery, design, development, and use. . fills a void in our knowledge of vaccine adjuvants, providing one authoritative text source for the latest information on this topic. The book meets the authors' objectives superbly. . it could serve as a reference for students, residents, and practitioners, particularly in the fields of infectious diseases and immunology. . It will serve as a valuable reference for those interested in this field." (Archana NMI Chatterjee, Doody's Review Service, July, 2006)