VEGF in Development

Hardcover | April 21, 2008

EditorChristiana Ruhrberg

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This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.In writing this book, scientists investigating different aspects of VEGF signalling have come together to highlight the central importance of this growth factor for vertebrate development. From their reviews of our present knowledge, it becomes clear that VEGF's versatility as a patterning molecule is linked to its expression as several splice forms that interact with a number of differentially expressed signalling receptors. Moreover, by highlighting the present gaps in our knowledge, the authors of this book set direction to future research. It is therefore hoped that this book will provide valuable insights to those already studying VEGF as well as to those members of the scientific and medical community that seek to understand vertebrate development and the origins of disease without specific prior knowledge of the field.

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From the Publisher

This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a fu...

Format:HardcoverDimensions:117 pages, 9.76 × 6.5 × 0 inPublished:April 21, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387786317

ISBN - 13:9780387786315

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Table of Contents

1. The Biology of Vascular Endothelial Cell Growth Factor Isoforms Yin-Shan Ng2. VEGF Receptor Signalling in Vertebrate Development Joaquim Miguel Vieira, Christiana Ruhrberg and Quenten Schwarz3. VEGF Gene Regulation Marcus Fruttiger4. Embryonic Vasculogenesis and Hematopoietic Specification Lauren C. Goldie, Melissa K. Nix and Karen K. Hirschi5. Role of VEGF in Organogenesis Jody J. Haigh6. VEGF and Endothelial Guidance in Angiogenic Sprouting Holger Gerhardt7. Vascular and Nonvascular Roles of VEGF in Bone Development Christa Maes and Geert Carmeliet8. VEGF in the Nervous System Jeffrey M. Rosenstein, Janette M. Krum and Christiana Ruhrberg