Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery by Bryan FryVenomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery by Bryan Fry

Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery

EditorBryan Fry

Hardcover | May 5, 2015

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Venom research and technology has advanced greatly, rapidly transforming our knowledge of reptile venoms. Research advances, like the development of molecular systematics, provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developmentshave expanded our understanding of venom's evolution and its usefulness in therapeutic development. The results of this punctuated toxin molecular evolutionary expansion include protein neofunctionalization. While these changes may impact antivenom efficacy, this molecular diversity also facilitatestheir usefulness in the development of novel drug therapies.Venomous Reptiles And Their Toxins brings together the world's leading toxinologists in this comprehensive study of the entire scope of reptile venoms, from clinical effects to evolution to drug design and development. The book contains detailed applied chapters on clinical care of the envenomedpatient, ineffective traditional or modern remedies, occupational considerations involved in the maintenance of institutional venomous reptile collections, veterinary care for venomous reptiles and research methods used in venom research. This book also devotes a chapter to each toxin class found inreptile venoms, detailing the full trajectory of research on the peptide or protein in question. These chapters discuss each toxin's respective role in the envenomation process through to how each has been explored for their biomedical potential. This book is a unique resource for anyone workingwith venomous reptiles.
Bryan G. Fry is an Associate Professor in the School of Biological Sciences at the University of Queensland. He leads the Venom Evolution Laboratory, working on venoms from a wide diversity of reptiles, centipedes, cnidarians, insects, scorpions, spiders and even venomous mammals. He has published extensively on venom systems evolution...
Title:Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and BiodiscoveryFormat:HardcoverDimensions:576 pages, 10.12 × 7.2 × 1.5 inPublished:May 5, 2015Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199309396

ISBN - 13:9780199309399


Table of Contents

1. The origin and evolution of the Toxicofera reptile venom system2. Signs, symptoms and treatment of envenomation3. Antivenom research and development4. Ineffective traditional and modern techniques for the treatment of snakebite5. Maintaining venomous animal collections: protocols and occupational safety6. Veterinary care of venomous reptiles7. Research methods8. Three finger toxins (3FTx)9. Beta-defensins10. Cysteine-rich secretory proteins (TV-CRiSP)11. Exendin peptides12. Factor Va proteins (TV-fVa)13. Factor Xa enzymes (TV-fXa)14. Kallikrein enzymes (TV-kallikrein)15. Kunitz peptides (TV-kunitz)16. L-amino acid oxidase enzymes (TV-LAAO)17. Lectin peptides (TV-lectin)18. Lizard venom B-type natriuretic peptides (LV-BNP)19. Snake venom C-type natriuretic peptides (SV-CNP)20. Group-I phospholipase A2 enzymes (TV-PLA2-GI)21. Group-II phospholipase A2 enzymes (TV-PLA2-GII)22. Sarafotoxin peptides23. Snake venom metalloprotease enzymes (SVMP)24. Lesser-known or putative reptile toxins25. Poisonous snakes and bacteria as a Komodo dragon weapon: which is a myth and which is reality?ContributorsList of Abbreviations