Viral Replication Complexes: Structures, Functions, Applications and Inhibitors by David D. BoehrViral Replication Complexes: Structures, Functions, Applications and Inhibitors by David D. Boehr

Viral Replication Complexes: Structures, Functions, Applications and Inhibitors

Guest editorDavid D. Boehr

Hardcover | July 15, 2016

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Viruses are obligate intracellular parasites that need to co-opt a living cell’s machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome. This process must often be coordinated with other viral processes, including protein translation and viral packaging. The polymerases and other components of the replication machinery may serve as potential anti-viral targets.

Section 1 of this book is devoted to the basic structure–function relationships of viral nucleic acid polymerases and related proteins. Section 2 then discusses how interactions between the viral polymerase and viral nucleic acids and other proteins help to coordinate nucleic acid synthesis and other important viral processes. Section 3 builds on this discussion by including the roles of host proteins in these processes. Many viruses also co-opt host lipid membranes to provide more conducive environments for RNA synthesis and virus replication, which is discussed in Section 4. Finally, many of the processes discussed in the preceding sections are potential antiviral drug targets, which is discussed in Section 5.

Title:Viral Replication Complexes: Structures, Functions, Applications and InhibitorsFormat:HardcoverProduct dimensions:444 pages, 9.61 × 6.69 × 1.38 inShipping dimensions:9.61 × 6.69 × 1.38 inPublished:July 15, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038421677

ISBN - 13:9783038421672


Table of Contents

Chapter 1: Molecular Perspectives on Virus Replication ProteinsRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure toRegulatory MechanismsUsing the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model toUnderstand Viral Polymerase Structure, Function and DynamicsNucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-DependentRNA PolymeraseConformational Ensemble of the Poliovirus 3CD Precursor Observed by MDSimulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?Chapter 2: Coordinated Interactions of Viral Proteins and NucleicAcidsCoordinated DNA Replication by the Bacteriophage T4 ReplisomeHIV Rev Assembly on the Rev Response Element (RRE): A Structural PerspectiveTranslational Control of the HIV Unspliced Genomic RNAFlaviviral Replication Complex: Coordination between RNA Synthesis and 5'-RNA CappingModes of Human T Cell Leukemia Virus Type 1 Transmission,Replication and PersistenceChapter 3: Interplay Between Virus and Host in Virus ReplicationHIV-1 Replication and the Cellular Eukaryotic Translation ApparatusReprinted from: Viruses 2015, 7(1), 199-218APOBEC3 Interference during Replication of Viral GenomesHydrogen Peroxide Induce Human Cytomegalovirus Replication through theActivation of p38-MAPK Signaling PathwayBoth ERK1 and ERK2 Are Required for Enterovirus 71 (EV71) Efficient ReplicationChapter 4: Virus Replication OrganellesThe Virus-Host Interplay: Biogenesis of +RNA Replication ComplexesThe Role of Electron Microscopy in Studying the Continuum of Changes inMembranous Structures during Poliovirus InfectionAmino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds toHighly Curved LiposomesChapter 5: Antiviral DrugsAnti-HBV Drugs: Progress, Unmet Needs, and New HopeReplication and Inhibitors of Enteroviruses and Parechoviruses