Viral Vectors for Gene Therapy: Methods and Protocols by Curtis A. MachidaViral Vectors for Gene Therapy: Methods and Protocols by Curtis A. Machida

Viral Vectors for Gene Therapy: Methods and Protocols

EditorCurtis A. Machida

Paperback | November 9, 2010

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Researchers from academia and biotechnology describe proven molecular methods for the construction, development, and use of virus vectors for gene transfer and gene therapy. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system. Comprehensive and highly practical, Viral Vectors for Gene Therapy: Methods and Protocols provides not only researchers with the basic tools needed to design targeted gene delivery vectors, but also clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders.
Title:Viral Vectors for Gene Therapy: Methods and ProtocolsFormat:PaperbackDimensions:608 pages, 9.02 × 5.98 × 0 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617373087

ISBN - 13:9781617373084

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Table of Contents

Use of the Herpes Simplex Viral Genome to Construct Gene Therapy VectorsEdward A. Burton, Shaohua Huang, William F. Goins, and Joseph C. GloriosoConstruction of Multiply Disabled Herpes Simplex Viral Vectors for Gene Delivery to the Nervous SystemCaroline E. Lilley and Robert S. CoffinImproved HSV-1 Amplicon Packaging System Using ICP27-Deleted, Oversized HSV-1 BAC DNAYoshinaga Saeki, Xandra O. Breakefield, and E. Antonio ChioccaHerpes Simplex Amplicon VectorsCharles J. Link, Nicholas N. Vahanian, and Suming WangStrategies to Adapt Adenoviral Vectors for Targeted DeliveryCatherine R. O'Riordan, Antonius Song, and Julia LanciottiUse of Recombinant Adenovirus for Gene Transfer into the Rat Brain: Evaluation of Gene Transfer Efficiency, Toxicity, and Inflammatory and Immune ReactionsAndres Hurtado-Lorenzo, Anne David, Clare Thomas, Maria G. Castro, and Pedro R. LowensteinGeneration of Adenovirus Vectors Devoid of All Virus Genes by Recombination Between Inverted RepeatsHartmut Stecher, Cheryl A. Carlson, Dmitry M. Shayakhmetov, and André LieberPackaging Cell Lines for Generating Replication-Defective and Gutted Adenoviral VectorsJeffrey S. Chamberlain, Catherine Barjot, and Jeannine ScottImproving the Transcriptional Regulation of Genes Delivered by Adenovirus VectorsSemyon Rubinchik, Jan Woraratanadharm, Jennifer Schepp, and Jian-yun DongTargeted Integration by Adeno-Associated VirusMatthew D. Weitzman, Samuel M. Young, Jr., Toni Cathomen, and Richard Jude SamulskiDevelopment and Optimization of Adeno-Associated Virus Vector Transfer into the Central Nervous SystemMatthew J. During, Deborah Young, Kristin Baer, Patricia Lawlor, and Matthias KlugmannA Method for Helper Virus-Free Production of Adeno-Associated Virus VectorsRoy F. Collaco and James P. TrempeNovel Tools for Production and Purification of Recombinant Adeno-Associated Viral VectorsJulian D. Harris, Stuart G. Beattie, and J. George DicksonRecombinant Adeno-Associated Viral Vector Types 4 and 5: Preparation and Application for CNS Gene TransferBeverly L. Davidson and John A. ChioriniTrans-Splicing Vectors Expand the Packaging Limits of Adeno-Associated Virus for Gene Therapy ApplicationsDongsheng Duan, Yongping Yue, Ziying Yan, and John F. EngelhardtGeneration of Retroviral Packaging and Producer Cell Lines for Large-Scale Vector Production with Improved Safety and TiterThomas W. Dubensky, Jr. and Sybille L. SauterAn Ecdysone-Inducible Expression System for Use with RetrovirusesKaren Morse and John OlsenIn Vivo Infection of Mice by Replication-Competent MLV-Based Retroviral VectorsEstanislao Bachrach, Mogens Duch, Mireia Pelegrin, Hanna Dreja, Finn Skou Pedersen, and Marc PiechaczykDevelopment of Simian Retroviral Vectors for Gene DeliveryBiao Li and Curtis A. MachidaSelf-Inactivating Lentiviral Vectors and a Sensitive Cre-loxP Reporter SystemLung-Ji Chang and Anne-Kathrin ZaissLentiviral Vectors for Gene Transfer to the Central Nervous System: Applications in Lysosomal Storage Disease Animal ModelsDeborah J. Watson and John H. WolfeA Highly Efficient Gene Delivery System Derived from Feline Immunodeficiency Virus (FIV)Sybille L. Sauter, Medhi Gasmi, and Thomas W. Dubensky, JrA Multigene Lentiviral Vector System Based on Differential SplicingYonghong Zhu and Vicente PlanellesProduction of Trans-Lentiviral Vector with Predictable SafetyJohn C. Kappes, Xiaoyun Wu, and John K. WakefieldHuman Immunodeficiency Virus Type 1-Based Vectors for Gene Delivery to Human Hematopoietic Stem CellsAli Ramezani and Robert G. HawleySemliki Forest Viral Vectors for Gene TransferJarmo Wahlfors and Richard A. MorganSemliki Forest Virus (SFV) Vectors in Neurobiology and Gene TherapyKenneth Lundstrom and Markus U. EhrengruberSemliki Forest Virus Vectors for Large-Scale Production of Recombinant ProteinsKenneth LundstromDevelopment of Foamy Virus Vectors, George VassilopoulosNeil C. Josephson, and Grant TrobridgePoxviral/Retroviral Chimeric Vectors Allow Cytoplasmic Production of Transducing Defective Retroviral ParticlesGeorg W. Holzer and Falko G. FalknerIndex

Editorial Reviews

"This text would be very good for someone who can appreciate the many and varied practical aspects of performing a gene therapy study. I would certainly recommend it to anyone I knew working in the gene therapy field as a book to compare and contrast practical approaches and requirements for various viral vectors." - Pharmaceutical Research