Virus Dynamics: Mathematical Principles of Immunology and Virology

Paperback | July 15, 1999

byMartin Nowak, Robert M. May

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We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreedunderstanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in thisaccessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how thisapproach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches describedwill be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. Thepractical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study.

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We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreedunderstanding of the ultimate course and variability...

Martin Nowak is at Institute for Advanced Study, Princeton. Robert M. May is at University of Oxford.

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Format:PaperbackPublished:July 15, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198504179

ISBN - 13:9780198504177

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Table of Contents

Preface1. Introduction: Viruses, immunity, equations2. HIV3. The basic model of virus dynamics4. Anti-viral drug therapy5. Dynamics of hepatitis B virus6. Dynamics of immune responses7. How fast do immune responses eliminate infected cells?8. What is a quasispecies9. The frequency of resistant mutant virus before anti-viral therapy10. Emergence of drug resistance11. Timing the emergence of resistance12. Simple antigenic variation13. Advanced antigenic variation14. Multiple epitopes15. Everything we know so far and beyondAppendix A - Dynamics of resistance in different types of infected cellsAppendix B - Analysis of multiple epitope dynamics