Visualizing the Invisible: Imaging Techniques for the Structural Biologist

Hardcover | March 7, 2012

byPeter Moore

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Knowledge of the microscopic structure of biological systems is the key to understanding their physiological properties. Most of what we now know about this subject has been generated by techniques that produce images of the materials of interest, one way or another, and there is every reasonto believe that the impact of these techniques on the biological sciences will be every bit as important in the future as they are today. Thus the 21st century biologist needs to understand how microscopic imaging techniques work, as it is likely that sooner or later he or she will have to use oneor another of them, or will otherwise become dependent on the information that they provide. The objective of this textbook is to introduce its readers to the many techniques now available for imaging biological materials, e.g. crystallography, optical microscopy and electron microscopy, at a level that will enable them to use them effectively to do research. Since all of these experimentalmethods are best understood in terms of Fourier transformations, this book explains the relevant concepts from this branch of mathematics, and then illustrates their elegance and power by applying them to each of the techniques presented. The book is derived from a one-term course in structural biology that the author gave for many years at Yale. It is intended for students interested either in doing structural research themselves, or in exploiting structural information produced by others. Over the years, the course was takensuccessfully by advanced undergraduates and by graduate students. Scientists interested in entering the structural biology field later in their careers may also find it useful.

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Knowledge of the microscopic structure of biological systems is the key to understanding their physiological properties. Most of what we now know about this subject has been generated by techniques that produce images of the materials of interest, one way or another, and there is every reasonto believe that the impact of these techniq...

Peter Moore is a biophysical chemist who got his Ph.D. at Harvard with J.D. Watson, and spent most of his subsequent career at Yale. He is best known for his work on the three-dimensional structure of the ribosome, which he pursued using a wide variety of biophysical methods.

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Format:HardcoverDimensions:368 pages, 9.25 × 6.12 × 0.98 inPublished:March 7, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199767092

ISBN - 13:9780199767090

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Table of Contents

Part 1. Fundamental Concepts1. On the Scattering of Electromagnetic Radiation by Atoms and Molecules2. Molecular Scattering and the Fourier Transform3. Scattering by Condensed Phases: a More Sophisticated Look at Atomic and Molecular ScatteringAppendix 3.3: Energy absorption and the imaginary part of ?.Part 2. Crystallography4. On the Diffraction of X-rays by Crystals5. On the Appearance of Crystalline Diffraction Patterns6. Solving the Phase Problem7. Electron Density Maps and Molecular StructuresPart 3. Non-Crystallographic Diffraction8. Diffraction from Non-Crystalline SamplesPart 4. Optical Microscopy9. Image Formation Using Lenses10. The Light MicroscopePart 5. Electron Microscopy11. Lenses that Focus Electrons12. Image Formation in the Electron Microscope13. Electron Microscopy in Three DimensionsAppendix 13.1: Solving least squares problemsAppendix 13.2: Error propagation in linear systemsAppendix 13.3: The Fourier transform in cylindrical coordinates