Vitamin D: Volume 1: Biochemistry, Physiology And Diagnostics

Hardcover | September 1, 2017

byDavid FeldmanEditorJ. Wesley Pike, Roger Bouillon

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International experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted vitamin D. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease. Offers a comprehensive reference ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Volume I targets chemistry, metabolism and circulation; mechanisms of action; mineral and bone homeostasis; targets; human physiology; diagnosis and management; nutrition, sunlight, genetics and vitamin D deficiency Volume II presents a clinical focus on disorders; analogs; cancer; immunity, inflammation and disease; and therapeutic applications

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International experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted vitamin D. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back i...

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D r...

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Format:HardcoverDimensions:1026 pages, 9.41 × 7.24 × 0.98 inPublished:September 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128099658

ISBN - 13:9780128099650

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Table of Contents

Volume 1: Biochemistry, Physiology and Diagnostics

Preface David Feldman, J. Wesley Pike, Roger Bouillon, Edward Giovannucci, David Goltzman and Martin Hewison

In Memoriam: Robert P. Heaney, MD (1928-2016) Robert R. Recker and Joan M. Lappe In Memoriam: Milan Uskokovic, PhD (1924-2015) Sylvia Christakos, Hubert Maehr, and Nanjoo Suh

Section I. History, Chemistry Metabolism, Circulation & Regulation 1. Historical Overview of Vitamin D Hector F. DeLuca 2. Evolutionary Biology: Mysteries of Vitamin D in Fish David R. Fraser 3. Evolution of Human Skin Color and Vitamin D Nina G. Jablonski 4. Photobiology of Vitamin D Michael F. Holick 5. The Activating Enzymes of Vitamin D Metabolism (25- and 1± -Hydroxylases) Glenville Jones, David E. Prosser, and Martin Kaufmann 6. CYP24A1: Structure, Function, and Physiological Role René St-Arnaud and Glenville Jones 7. The Vitamin D Binding Protein DBP Roger Bouillon and Steven Pauwels 8. Regulation of renal and extra-renal 1± -hydroxylase Dean P. Larner, John S. Adams, and Martin Hewison

Section II. Mechanism of Action 9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells J. Wesley Pike, Mark B. Meyer, Seong Min Lee, Melda Onal, and Nancy Benkusky 10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor John H. White, Reyhaneh Salehi-Tabar, Vassil Dimitrov, and Manuella Bouttier 11. Structural basis for ligand activity in VDR Anna Y. Belorusova and Natacha Rochel 12. Ligand Independent Actions of Vitamin D Receptor Gilles Laverny and Daniel Metzger 13. Vitamin D and Chromatin Carsten Carlberg 14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR Mark B. Meyer, Nancy A. Benkusky, J. Wesley Pike 15. Vitamin D and microRNAs Hengguang Zhao, Sri Ramulu N. Pullagura, Sandra Rieger and Thomas S. Lisse 16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions Mathew T. Mizwicki, Anthony W. Norman

Section III. Mineral and Bone Homeostasis 17. Vitamin D Regulation of Osteoblast Function Jeroen van de Peppel, Renny T. Franceschi, Yan Li, and Bram C.J. van der Eerden 18. Osteoclastogenesis and Vitamin D Yuko Nakamichi, Naoyuki Takahashi, Nobuyuki Udagawa, and Tatsuo Suda 19. Vitamin D Activities in Osteocytes Paul H. Anderson, Gerald J. Atkins, Howard A. Morris, and David M. Findlay 20. Regulation of Intestinal Calcium and Phosphate Absorption James C. Fleet 21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 Sylvia Christakos, Leila J. Mady, and Puneet Dhawan 22. Calcium homeostasis and eggshell biomineralization in female chicken Yves Nys and Nathalie Le Roy 23. Mineralization in Mammals Adele L. Boskey 24. Cartilage Barbara D. Boyan, Maryam Doroudi, Kayla Scott, and Zvi Schwartz 25. Vitamin D and Bone: An Integrated Approach Geert Carmeliet

Section IV. Extra-Skeletal Targets 26. Vitamin D and the Kidney Peter J. Tebben and Rajiv Kumar 27. Vitamin D and the Parathyroids Justin Silver and Tally Naveh-Many 28. The Calcium-sensing Receptor and Vitamin D Geoffrey N. Hendy 29. Vitamin D in Dentoalveolar and Oral Health Brian L. Foster and Philippe P. Hujoel 30. The Role of Vitamin D and its Receptor in Hair Follicle Biology Marie B. Demay 31. Vitamin D, Calcium and the Epidermis Daniel D Bikle 32. Vitamin D and the Cardiovascular System Amy E. Riek, Rithwick Rajagopal, and Carlos Bernal-Mizrachi 33. Vitamin D Brain Development and Function Darryl Eyles and John McGrath 34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms Carmen J. Narvaez, Donald G. Matthews, and JoEllen Welsh 35. Vitamin D and Skeletal Muscle Christian M. Girgis 36. Understanding Vitamin D from mouse knockout models David Goltzman, Geoffrey N. Hendy, Andrew C. Karaplis, Richard Kremer, Denshun Miao

Section V. Human Physiology 37. Pharmacology and pharmacokinetics Inez Schoenmakers and Kerry S. Jones 38. Vitamin D Role in the Calcium and Phosphorus Economies Robert P. Heaney and Laura A.G. Armas 39. Fetus, Neonate and Infant Christopher S. Kovacs 40. Consequences of perinatal vitamin D deficiency on later bone health Cyrus Cooper, Elizabeth M. Curtis, Rebecca J. Moon, Elaine M. Dennison, and Nicholas C. Harvey 41. Adolescence and Acquisition of Peak Bone Mass Richard Lewis, Emma Laing, and Connie Weaver 42. Pregnancy, Lactation, and Post-Weaning Recovery Christopher S. Kovacs 43. Role in Reproductive Biology and Reproductive Dysfunction in Women Lubna Pal and Hugh S. Taylor 44. Vitamin D, reproductive biology, and dysfunction in men Ida Marie Boisen, Lasse Bollehuus Hansen, Li Juel Mortensen, and Martin Blomberg Jensen 45. Vitamin D and the Renin-Angiotensin System Yan Chun Li 46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin John J. Wysolmerski 47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity L. Darryl Quarles

Section VI. Diagnosis and Management 48. Approach to the Patient with Metabolic Bone Disease Michael P. Whyte 49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology Fabrizio Bonelli, and Bruce W. Hollis 50. Mass Spectrometry Assays of Vitamin D Metabolites Martin Kaufmann, Lusia Sepiashvili, and Ravinder J. Singh 51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects Rene F. Chun and Carrie M. Nielson 52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation Christopher T. Sempos, Graham D. Carter, and Neil C. Binkley 53. Bone Histomorphometry Juliet Compston, Linda Skingle, and David W. Dempster 54. Radiology of Rickets and Osteomalcia Judith E. Adams 55. High-resolution Imaging Techniques for Bone Quality Assessment Andrew J. Burghardt, Roland Krug, Sharmila Majumdar 56. The Role of Vitamin D in Orthopedic Surgery Aasis Unnanuntana, Aleksey Dvorzhinskiy, Brian J. Rebolledo, Shevaun M. Doyle, Panagiota Andreopoulou, and Joseph M. Lane Introduction to chapters 57 a and b 57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position Roger Bouillon and Cliff Rosen 57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position Reinhold Vieth and Michael F. Holick