West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response

Hardcover | December 2, 2008

EditorMichael S. Diamond

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West Nile virus is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans. Infection of humans is associated with a febrile illness that can progress to meningitis and encephalitis with symptoms including cognitive dysfunction and flaccid paralysis. Following its introduction to the United States in 1999, West Nile virus rapidly disseminated across North America. Outbreaks of West Nile virus fever and neuroinvasive disease now occur annually in the United States, with about 23,000 diagnosed human cases between 1999 and 2006, and likely millions of undiagnosed infections. At present no vaccines or specific therapies for West Nile virus are currently approved for humans. The emergence of West Nile virus in the Western hemisphere and the corresponding increase in disease burden has been accompanied by intensive study. West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response focuses on recent studies that have identified key steps in the molecular pathogenesis of West Nile virus infection. After introducing the scale of the global problem, the genetic diversity, and the clinical syndromes, the initial chapters describe our most up-to-date understanding of the pathogenesis steps in animals and the viral sequence determinants that mediate virulence. Subsequent chapters focus on the earliest innate host immune response that controls West Nile virus spread and include recent experiments on pathogen recognition receptors, IFN antiviral cascades, and mechanisms of West Nile virus antagonism. The book explores in detail the host-pathogen interface, and analyzes the latest data describing how a balance between host protective responses, host immunopathology, West Nile-induced pathology, and West Nile virus immune evasion determines infection outcome. Finally, the book concludes with novel approaches and prospects for human vaccines and therapeutics. About the Editor:Dr. Michael S. Diamond is Associate Professor in the Division of Infectious Diseases at Washington University Medical School, St. Louis, MO, uSA.

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From the Publisher

West Nile virus is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans. Infection of humans is associated with a febrile illness that can progress to meningitis and encephalitis with symptoms including cognitive dysfunction and flaccid paralysis. Following its introduction to the Un...

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In West Nile Encephalitis Virus Infection, leading scientists and researchers discuss the West Nile virus, a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Its appearance in the Western Hemisphere in 1999, and the corresponding increase in global disease burden over the last decade has been a...

Format:HardcoverDimensions:504 pages, 9.25 × 6.1 × 0.27 inPublished:December 2, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387798390

ISBN - 13:9780387798394

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Table of Contents

Global Epidemiology of West Nile Virus.- West Nile virus: Molecular epidemiology and diversity.- Vector biology and West Nile virus.- Clinical Manifestations of Neurological Disease.- Molecular Biology of West Nile Virus.- Virulence of West Nile virus in different animal hosts.- Innate immune response and mechanisms of IFN antagonism against WNV.- Innate immune responses to West Nile virus infection.- Mechanisms of Complement Regulation of Infection by Flaviviruses.- Antibody-mediated neutralization of West Nile virus: Factors that govern neutralization potency.- Structural basis of antibody protection against West Nile virus.- Molecular Mechanisms of Flaviviral Membrane Fusion.- CD4+ and CD8+ T cell immune responses in West Nile virus infection.- Enhanced antigen processing or immune evasion?- West Nile virus and the induction of immune recognition molecules.- Chemokines and Clearance of West Nile Virus Infection.- Persistence of West Nile Virus Infection in Vertebrates.- West Nile Virus Infection of the Central Nervous System.- The Human antibody response against WNV.- Antibody protection and therapy for West Nile virus infections.- Vaccine development against West Nile virus.- Novel therapeutics against West Nile virus.