Critical Pathways to Success in CNS Drug Development de Neal R. CutlerCritical Pathways to Success in CNS Drug Development de Neal R. Cutler

Critical Pathways to Success in CNS Drug Development

deNeal R. Cutler, John J. Sramek, Michael F. Murphy

Couverture rigide | 26 avril 2010 | Anglais

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description

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials.

The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future.

Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed.

Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

Titre :Critical Pathways to Success in CNS Drug DevelopmentFormat :Couverture rigideDimensions :272 pages, 9,3 × 6,3 × 0,82 poPublié le :26 avril 2010Publié par :WileyLangue :Anglais

Les ISBN ci-dessous sont associés à ce titre :

ISBN - 10 :1444330640

ISBN - 13 :9781444330649

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Table des matières

Acknowledgements.

Foreword.

1 The Impending Crisis in CNS Drug Development.

2 Animal Models and Procedures for CNS Disorders.

3 Pre-Clinical Antecedents to Early Human Clinical Trials.

4 Biomarkers and Surrogate Markers in Drug Development.

5 Neuroimaging and Cognitive Assessments in Early Drug Development.

6 Bridging and CSF Studies.

7 A Case Study from Pre-Clinical to Early Clinical Trials.

Index.