ADAMTS13: Biology and Disease by George M. RodgersADAMTS13: Biology and Disease by George M. Rodgers

ADAMTS13: Biology and Disease

byGeorge M. Rodgers

Hardcover | September 15, 2015

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This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease,ADAMTS13: Biology and Diseaseis a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.

Dr. George M. Rodgers received his M.D. and Ph.D. in Pharmacology from Tulane University Medical School in New Orleans, Louisiana. He completed his internal medicine training at Baylor College of Medicine in Houston, Texas, along with a hematology fellowship at the University of California, San Francisco, and served on the UCSF faculty...
Title:ADAMTS13: Biology and DiseaseFormat:HardcoverDimensions:186 pagesPublished:September 15, 2015Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319087169

ISBN - 13:9783319087160

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Table of Contents

1. A13: Structure and function.- 2. A13: The von Willebrand factor cleaving protease.- 3. A13: Angiogenesis and other biologic activities.- 4. A13: Assays.- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome).- 6. Acquired A13 deficiency (TTP).- 7. Related thrombotic microangiopathies.- 8. Future directions.

Editorial Reviews

"The purpose is toprovide a current overview of ADAMTS13, spanning basic science and clinicalmedicine. . of interest to any medical students, residents, practicingphysicians, or allied health practitioners involved in the care of thesepatients. . If you are even remotely interested in ADAMTS13, you must get thisbook. This is most certainly one of the best current reviews of this subjectavailable today." (Valerie L. Ng, Doody's Book Reviews, November, 2015)