Neural Tube Defects: From Origin To Treatment

Hardcover | October 15, 2005

EditorDiego F. Wyszynski

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Neural tube defects affect about 4000 pregnancies each year and are thus among the most common of severe birth defects. Prenatal diagnosis can now detect about 70% of neural tube defects but the tests produce many false positives, so the question is under what circumstances should they berecommended. This comprehensive volume - the collective knowledge of more than 55 experts in the field - provides lucid and authoritative discussions on this topic as well as on a wide variety of theoretical, experimental, and clinical issues.

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Neural tube defects affect about 4000 pregnancies each year and are thus among the most common of severe birth defects. Prenatal diagnosis can now detect about 70% of neural tube defects but the tests produce many false positives, so the question is under what circumstances should they berecommended. This comprehensive volume - the co...

Diego F. Wyszynski is at Boston University School of Medicine and School of Public Health.

other books by Diego F. Wyszynski

Format:HardcoverDimensions:424 pages, 8.7 × 10.91 × 1.3 inPublished:October 15, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195166035

ISBN - 13:9780195166033

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Table of Contents

SECTION I BASIC PRINCIPLES. Part I Clinical and Molecular Embryology of the Central Nervous System. 1. Marianne Bronner-Fraser: Neural Crest Formation2. Nicholas D.E. Greene, Andrew J. Copp: The Embryonic Basis of Neural Tube Defects3. Hakryul Jo, Laura Anne Lowery, Vincent Tropepe, Hazel Sive: The Zebrafish as a Model for Analyzing Neural Tube Defects4. Ellen M. Carpenter: Genetic Regulation of Early Nervous System DevelopmentPart II Clinical Features of Neural Tube Defects. 5. Stuart L. Weinstein, Sergio A. Mendoza: Physical Examination of the Spine6. Classification of Neural Tube Defects Cynthia A. Moore7. Roger E. Stevenson, Laurie H. Seaver: Syndromes with Neural Tube Defects8. Cary R. Templin, John F. Sarwark: The Tethered Cord Syndrome9. Glenn J. Gardener, Charles H. Rodeck: Prenatal Screening and Diagnosis of Neural Tube DefectsPart III Epidemiology of Neural Tube Defects. 10. Russell S. Kirby: Methodological Issues in the Study of Neural Tube Defects11. Lowell E. Sever: Birth Defects Surveillance Systems and Neural Tube Defects12. Rolv T. Lie: An International Perspective on Anencephaly and Spina Bifida: Prevalences by the Turn of the Century13. Diego F. Wyszynski: Maternal Exposure to Selected Environmental Factors and Risk for Neural Tube Defects in the OffspringPart IV. Genetics of Neural Tube Defects. 14. Evadnie Rampersaud, Elizabeth C. Melvin, Marcy C. Speer: Nonsyndromic Neural Tube Defects: Genetic Basis and Genetic Investigations15. Rima Rozen: Genetic Risk Factors for Neural Tube Defects: Variants in Folate Metabolism16. Sonja A. Rasmussen, Jaime L. Frias: Genetics of Syndromic Neural Tube Defects17. Andrew J. Copp, Nicholas D.E. Greene, Jennifer N. Murdoch: Mouse Mutants as Models of Neural Tube DefectsSECTION II TREATMENT AND EDUCATION. 18. Kelly A. Bennett, George H. Davis, Noel Tulipan, Joseph P. Bruner: Fetal Surgery for Myelomeningocele19. Jonathan P. Miller, Alan R. Cohen: Postnatal Surgery for Myelomeningocele20. Harold L. Rekate: Neurosurgical Management of Adults with Spina Bifida21. Luciano Dias: Orthopedic Surgery22. David B. Joseph: Urological Care and Management of Patients with Neural Tube Defects23. Gregory S. Liptak: Cognition, Education, and Learning Disorders24. Gregory S. Liptak: Transition to Adulthood25. David B. Shurtleff, Carole A. Sobkowiak, William Walker: Transition/Separation, Toilet Training, and Sexuality26. Rachel Neff Greenley, Grayson N. Holmbeck, Jill Zukerman, Colleen F. Buck: Psychological Adjustment and Family Relationships in Children and Adolescents with Spina Bifida27. Sonya G. Oppenheimer: When and How to Communicate with People with Spina Bifida and Their Families28. Robert A. Saul: Genetic Counseling and Interpretation of Risk FiguresSECTION III PUBLIC HEALTH ISSUES. 29. Godfrey P. Oakley, Jr.: Preventing All Folic Acid-Preventable Spina Bifida30. Norman J. Waitzman, Patrick S. Romano, Scott D. Grosse: The Half-Life of Cost-of-Illness Estimates: The Case of Spina Bifida31. Holly Grason, Jamie J. Perry: Insurance and Coverage of Care for Individuals with Spina Bifida and Other Neural Tube Defects32. Jim Stevenson, Ineke M. Pit-Ten Cate: Assessment of Health-Related Quality of Life in Individuals with Neural Tube Defects33. Mark J. Bliton: Ethics at the Forefront: Moral Decisions and Responsibility When Confronted with Spina Bifida

Editorial Reviews

"This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating."--Human Genetics